PMID- 36975852
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2409-515X (Electronic)
IS  - 2409-515X (Linking)
VI  - 9
IP  - 1
DP  - 2023 Mar 1
TI  - Sickle Cell Disease Newborn Screening-An Audit of a Twin Island State Pilot 
      Program.
LID - 10.3390/ijns9010014 [doi]
LID - 14
AB  - The prevalence of Sickle Cell Disease (SCD) within the Caribbean region remains 
      second only to that of West Africa. The Newborn Screening (NBS) Program in 
      Antigua and Barbuda remains heavily dependent on grants, therefore ultimately 
      facing sustainability challenges. Early intervention and implementation of 
      preventative measures post-NBS result in significant improvements in morbidity, 
      quality of life, and survival. This audit reviewed the pilot SCD NBS Program in 
      Antigua and Barbuda from September 2020 to December 2021. A conclusive result was 
      received by 99% of babies eligible for screening, 84.3% of which were HbFA, 
      whilst 9.6% and 4.6% were HbFAS and HbFAC, respectively. This was comparable to 
      other Caribbean countries. Sickle Cell Disease was noted in 0.5% of babies 
      screened, which translates to 1 in 222 live births. Eighty-two percent of mothers 
      were aware of their sickle cell status, compared to 3% of fathers. The importance 
      of instituting a quality improvement team post the initiation of a screening 
      program and the need for a robust public education program have been demonstrated 
      by this audit.
FAU - Belle Jarvis, Shivon
AU  - Belle Jarvis S
AD  - Paediatric Department, Sir Lester Bird Medical Centre, Michael's Mount, St. 
      John's, Antigua and Barbuda.
FAU - Hadeed, Edda
AU  - Hadeed E
AD  - Gambles Medical Centre, Friars Hill Road, St. John's, Antigua and Barbuda.
FAU - Lee, Ketty
AU  - Lee K
AD  - Laboratory of Molecular Genetics and Inherited Disorders of Red Blood Cell, 
      University Hospital of Guadeloupe, Guadeloupe, F.W.I, France.
FAU - Hardy-Dessources, Marie-Dominique
AU  - Hardy-Dessources MD
AUID- ORCID: 0000-0003-0861-3648
AD  - Universite des Antilles, UFR Medecine/Campus de Fouillolle-Universite Paris Cite, 
      Inserm, BIGR, 97159 Pointe-a-Pitre, France.
FAU - Knight-Madden, Jennifer M
AU  - Knight-Madden JM
AD  - Caribbean Institute for Health Research-Sickle Cell Unit, The University of the 
      West Indies, Mona, Kingston 7, Jamaica.
FAU - Richardson, Claudine
AU  - Richardson C
AD  - Paediatric Department, Sir Lester Bird Medical Centre, Michael's Mount, St. 
      John's, Antigua and Barbuda.
LA  - eng
PT  - Journal Article
DEP - 20230301
PL  - Switzerland
TA  - Int J Neonatal Screen
JT  - International journal of neonatal screening
JID - 101665400
PMC - PMC10052052
OTO - NOTNLM
OT  - Antigua and Barbuda
OT  - audit
OT  - newborn screening
OT  - sickle cell disease
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/29 06:00
MHDA- 2023/03/29 06:01
PMCR- 2023/03/01
CRDT- 2023/03/28 10:08
PHST- 2023/01/20 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/02/24 00:00 [accepted]
PHST- 2023/03/29 06:01 [medline]
PHST- 2023/03/28 10:08 [entrez]
PHST- 2023/03/29 06:00 [pubmed]
PHST- 2023/03/01 00:00 [pmc-release]
AID - ijns9010014 [pii]
AID - IJNS-09-00014 [pii]
AID - 10.3390/ijns9010014 [doi]
PST - epublish
SO  - Int J Neonatal Screen. 2023 Mar 1;9(1):14. doi: 10.3390/ijns9010014.