PMID- 36976053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Electronic)
IS  - 2079-4983 (Linking)
VI  - 14
IP  - 3
DP  - 2023 Feb 26
TI  - Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation.
LID - 10.3390/jfb14030129 [doi]
LID - 129
AB  - Mesoporous Bioactive Glasses (MBGs) are biomaterials widely used in tissue 
      engineering, particularly for hard tissue regeneration. One of the most frequent 
      postoperative complications following a biomaterial surgical implant is a 
      bacterial infection, which usually requires treatment by the systemic 
      administration of drugs (e.g., antibiotics). In order to develop biomaterials 
      with antibiotic properties, we investigated cerium-doped MBGs (Ce-MBGs) as in 
      situ-controlled drug delivery systems (DDSs) of gentamicin (Gen), a wide spectrum 
      antibiotic commonly employed against bacteria responsible of postoperative 
      infections. Here we report the optimization of Gen loading on MBGs and the 
      evaluation of the antibacterial properties and of retention of bioactivity and 
      antioxidant properties of the resulting materials. The Gen loading (up to 7%) was 
      found to be independent from cerium content, and the optimized Gen-loaded Ce-MBGs 
      retain significant bioactivity and antioxidant properties. The antibacterial 
      efficacy was verified up to 10 days of controlled release. These properties make 
      Gen-loaded Ce-MBGs interesting candidates for simultaneous hard tissue 
      regeneration and in situ antibiotic release.
FAU - Fraulini, Francesca
AU  - Fraulini F
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, 41125 Modena, Italy.
FAU - Raimondi, Stefano
AU  - Raimondi S
AUID- ORCID: 0000-0003-0944-6677
AD  - Department of Life Sciences, University of Modena and Reggio Emilia, 41125 
      Modena, Italy.
FAU - Candeliere, Francesco
AU  - Candeliere F
AUID- ORCID: 0000-0003-4950-5467
AD  - Department of Life Sciences, University of Modena and Reggio Emilia, 41125 
      Modena, Italy.
FAU - Ranieri, Raffaella
AU  - Ranieri R
AD  - Department of Life Sciences, University of Modena and Reggio Emilia, 41125 
      Modena, Italy.
FAU - Zambon, Alfonso
AU  - Zambon A
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, 41125 Modena, Italy.
FAU - Lusvardi, Gigliola
AU  - Lusvardi G
AUID- ORCID: 0000-0002-0772-6037
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, 41125 Modena, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230226
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC10054597
OTO - NOTNLM
OT  - antibacterial activity
OT  - bioactive glasses
OT  - bioactivity
OT  - cerium
COIS- There are no conflict to declare.
EDAT- 2023/03/29 06:00
MHDA- 2023/03/29 06:01
PMCR- 2023/02/26
CRDT- 2023/03/28 10:22
PHST- 2023/01/16 00:00 [received]
PHST- 2023/02/23 00:00 [revised]
PHST- 2023/02/25 00:00 [accepted]
PHST- 2023/03/29 06:01 [medline]
PHST- 2023/03/28 10:22 [entrez]
PHST- 2023/03/29 06:00 [pubmed]
PHST- 2023/02/26 00:00 [pmc-release]
AID - jfb14030129 [pii]
AID - jfb-14-00129 [pii]
AID - 10.3390/jfb14030129 [doi]
PST - epublish
SO  - J Funct Biomater. 2023 Feb 26;14(3):129. doi: 10.3390/jfb14030129.