PMID- 3697728
OWN - NLM
STAT- MEDLINE
DCOM- 19860602
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 368
IP  - 2
DP  - 1986 Mar 19
TI  - Oxytocin potently enhances novelty-induced grooming behavior in the rat.
PG  - 287-95
AB  - Intracerebroventricular (i.c.v.) injection of oxytocin was followed by an 
      enhancement of novelty-induced grooming in male and female rats. This effect was 
      dose-dependent, in a dose range of 0.1-10 micrograms. Grooming activity of rats 
      injected i.c.v. with 10 micrograms of oxytocin was 9-fold higher than that of 
      saline-injected controls. The analysis of behavioral element composition revealed 
      an increased occurrence of genital grooming in oxytocin-injected rats. A 
      time-course study revealed a sustained increase in grooming activity of 
      oxytocin-treated rats during 45 min of behavioral testing. Intraperitoneal (i.p.) 
      injection of the dopamine antagonist, haloperidol, totally suppressed 
      oxytocin-enhanced grooming. Furthermore, i.p. injection of the opiate receptor 
      antagonist, naloxone, was followed by an attenuation but not a suppression of 
      grooming enhanced by i.c.v. administration of oxytocin. In addition, a small but 
      significant increase in grooming activity was observed after subcutaneous 
      injection of oxytocin. These results suggest that oxytocin-enhanced grooming 
      behavior involves central mechanisms, e.g. dopamine and opioid transmission in 
      the brain.
FAU - Drago, F
AU  - Drago F
FAU - Pedersen, C A
AU  - Pedersen CA
FAU - Caldwell, J D
AU  - Caldwell JD
FAU - Prange, A J Jr
AU  - Prange AJ Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 36B82AMQ7N (Naloxone)
RN  - 50-56-6 (Oxytocin)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Female
MH  - Grooming/*drug effects
MH  - Haloperidol/administration & dosage/pharmacology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Male
MH  - Naloxone/administration & dosage/pharmacology
MH  - Oxytocin/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sex Characteristics
MH  - Time Factors
EDAT- 1986/03/19 00:00
MHDA- 2001/03/28 10:01
CRDT- 1986/03/19 00:00
PHST- 1986/03/19 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1986/03/19 00:00 [entrez]
AID - 0006-8993(86)90573-1 [pii]
AID - 10.1016/0006-8993(86)90573-1 [doi]
PST - ppublish
SO  - Brain Res. 1986 Mar 19;368(2):287-95. doi: 10.1016/0006-8993(86)90573-1.