PMID- 36979709
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 3
DP  - 2023 Feb 28
TI  - Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample.
LID - 10.3390/biomedicines11030730 [doi]
LID - 730
AB  - This study aimed to explore the role of telomere length in three different 
      diabetes types: latent autoimmune diabetes of adulthood (LADA), latent autoimmune 
      diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 
      patients were included, 72 (62.61%) had LADA, 30 (26.09%) had T2DM, and 13 
      (11.30%) had LADY. Telomere length was measured using real-time Polymerase Chain 
      Reaction. For statistical analysis, we used the ANOVA test, X2 test, and the 
      Mann-Whitney U test. Patients with T2DM had higher BMI compared to LADA and LADY 
      groups, with a BMI average of 31.32 kg/m(2) (p = 0.0235). While the LADA group 
      had more patients with comorbidities, there was not a statistically significant 
      difference (p = 0.3164, p = 0.3315, p = 0.3742 for each of the previously 
      mentioned conditions). There was a difference between those patients with T2DM 
      who took metformin plus any other oral antidiabetic agent and those who took 
      metformin plus insulin, the ones who had longer telomeres. LADA patients had 
      shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, 
      T2DM may have longer telomeres thanks to the protective effects of both metformin 
      and insulin, despite the higher BMI in this group.
FAU - Cuevas Diaz, Pavel
AU  - Cuevas Diaz P
AUID- ORCID: 0000-0001-7717-4541
AD  - Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National 
      Institute of Genomic Medicine (INMEGEN), Mexico City 01090, Mexico.
FAU - Nicolini, Humberto
AU  - Nicolini H
AUID- ORCID: 0000-0003-2494-0067
AD  - Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National 
      Institute of Genomic Medicine (INMEGEN), Mexico City 01090, Mexico.
FAU - Nolasco-Rosales, German Alberto
AU  - Nolasco-Rosales GA
AUID- ORCID: 0000-0001-5536-3173
AD  - Biomedical Postgraduate Program, Academic Division of Health Sciences, Juarez 
      Autonomous University of Tabasco, Villahermosa 86000, Mexico.
FAU - Juarez Rojop, Isela
AU  - Juarez Rojop I
AD  - Academic Division of Health Sciences, Juarez Autonomous University of Tabasco, 
      Villahermosa 86000, Mexico.
FAU - Tovilla-Zarate, Carlos Alfonso
AU  - Tovilla-Zarate CA
AUID- ORCID: 0000-0001-8170-8171
AD  - Biomedical Postgraduate Program, Academic Division of Health Sciences, Juarez 
      Autonomous University of Tabasco, Villahermosa 86000, Mexico.
AD  - Comalcalco Multidisciplinary Academic Division, Juarez Autonomous University of 
      Tabasco, Comalcalco 86040, Mexico.
FAU - Rodriguez Sanchez, Ester
AU  - Rodriguez Sanchez E
AD  - Diabetes Clinic, Hospital Regional de Alta Especialidad "Dr. Gustavo A. Roviosa 
      Perez", Villahermosa 86020, Mexico.
FAU - Genis-Mendoza, Alma Delia
AU  - Genis-Mendoza AD
AD  - Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National 
      Institute of Genomic Medicine (INMEGEN), Mexico City 01090, Mexico.
AD  - Psychiatric Attention Services, Hospital Psiquiatrico Infantil, "Dr. Juan N. 
      Navarro, Tlalpan", Mexico City 14080, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230228
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10045771
OTO - NOTNLM
OT  - Mexicans
OT  - diabetes
OT  - telomere length
OT  - telomere shortening
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/02/28
CRDT- 2023/03/29 01:20
PHST- 2023/01/25 00:00 [received]
PHST- 2023/02/18 00:00 [revised]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:20 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/02/28 00:00 [pmc-release]
AID - biomedicines11030730 [pii]
AID - biomedicines-11-00730 [pii]
AID - 10.3390/biomedicines11030730 [doi]
PST - epublish
SO  - Biomedicines. 2023 Feb 28;11(3):730. doi: 10.3390/biomedicines11030730.