PMID- 36979777
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 3
DP  - 2023 Mar 6
TI  - Tissue Engineering and Targeted Drug Delivery in Cardiovascular Disease: The Role 
      of Polymer Nanocarrier for Statin Therapy.
LID - 10.3390/biomedicines11030798 [doi]
LID - 798
AB  - Atherosclerosis-related coronary artery disease (CAD) is the leading cause of 
      mortality and morbidity worldwide. This requires effective primary and secondary 
      prevention in reducing the complications related to CAD; the regression or 
      stabilization of the pathology remains the mainstay of treatment. Statins have 
      proved to be the most effective treatment in reducing adverse effects, but there 
      are limitations related to the administration and achievement of effective doses 
      as well as side effects due to the lack of target-related molecular specificity. 
      The implemented technological steps are polymers and nanoparticles for the 
      administration of statins, as it has been seen how the conjugation of drug 
      delivery systems (DDSs) with statins increases bioavailability by circumventing 
      the hepatic-renal filter and increases the related target specificity, enhancing 
      their action and decreasing side effects. Reduction of endothelial dysfunction, 
      reduced intimal hyperplasia, reduced ischemia-reperfusion injury, cardiac 
      regeneration, positive remodeling in the extracellular matrix, reduced neointimal 
      growth, and increased reendothelialization are all drug-related effects of 
      statins enhanced by binding with DDSs. Recent preclinical studies demonstrate how 
      the effect of statins stimulates the differentiation of endogenous cardiac stem 
      cells. Poly-lactic-co-glycolic acid (PLGA) seems to be the most promising DDS as 
      it succeeds more than the others in enhancing the effect of the bound drug. This 
      review intends to summarize the current evidence on polymers and nanoparticles 
      for statin delivery in the field of cardiovascular disease, trying to shed light 
      on this topic and identify new avenues for future studies.
FAU - Montelione, Nunzio
AU  - Montelione N
AUID- ORCID: 0000-0003-0983-7045
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
FAU - Loreni, Francesco
AU  - Loreni F
AD  - Unit of Cardiac Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
FAU - Nenna, Antonio
AU  - Nenna A
AUID- ORCID: 0000-0002-4069-6781
AD  - Unit of Cardiac Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
FAU - Catanese, Vincenzo
AU  - Catanese V
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
FAU - Scurto, Lucia
AU  - Scurto L
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
FAU - Ferrisi, Chiara
AU  - Ferrisi C
AD  - Unit of Cardiac Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
FAU - Jawabra, Mohamad
AU  - Jawabra M
AD  - Unit of Cardiac Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
FAU - Gabellini, Teresa
AU  - Gabellini T
AD  - Residency Program of Vascular and Endovascular Surgery, University of Ferrara, 
      44121 Ferrara, Italy.
FAU - Codispoti, Francesco Alberto
AU  - Codispoti FA
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
FAU - Spinelli, Francesco
AU  - Spinelli F
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
FAU - Chello, Massimo
AU  - Chello M
AUID- ORCID: 0000-0001-8178-7068
AD  - Unit of Cardiac Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
FAU - Stilo, Francesco
AU  - Stilo F
AD  - Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 00128 Rome, 
      Italy.
AD  - Head of Research Unit of Vascular Surgery, Universita Campus Bio-Medico di Roma, 
      00128 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230306
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10045667
OTO - NOTNLM
OT  - atherosclerosis
OT  - cardiovascular disease
OT  - polymer
OT  - statin
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/03/06
CRDT- 2023/03/29 01:21
PHST- 2023/01/17 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/02/24 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:21 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/06 00:00 [pmc-release]
AID - biomedicines11030798 [pii]
AID - biomedicines-11-00798 [pii]
AID - 10.3390/biomedicines11030798 [doi]
PST - epublish
SO  - Biomedicines. 2023 Mar 6;11(3):798. doi: 10.3390/biomedicines11030798.