PMID- 36979797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 3
DP  - 2023 Mar 7
TI  - The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory 
      Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An 
      Explorative Study.
LID - 10.3390/biomedicines11030818 [doi]
LID - 818
AB  - Adolescence is often a challenging time in which psychiatric issues have a strong 
      connection to mental health disorders later in life. The early identification of 
      the problems can reduce the burden of disease. To date, the effective 
      identification of adolescents at risk of developing mental health problems 
      remains understudied. Altogether, the interaction between circulating cell-free 
      mtDNA (ccf-mtDNA) and inflammatory cytokines in adolescents is insufficiently 
      understood regarding experienced mental health difficulties. Our study selected 
      the participants based on the Strength and Difficulty Questionnaire (SDQ) score 
      using the cut-off points of 3 and 18 for the low and the high score groups, 
      respectively. The answers of the SDQ at the age of 12.2-15.7 years contributed to 
      the investigation of (i) whether ccf-mtDNA units are associated with cytokines, 
      and (ii) if an interaction model for predicting risk of mental health issues is 
      observed. We discovered a sex-specific correlation between the screened markers 
      associated with mental health problems in the low and high SDQ score groups among 
      the male participants and in the low SDQ score group among the female 
      participants. The mitochondrial MT-ND4 and MT-CO1 genes correlated significantly 
      with interleukin-12p70 (IL-12p70) in males and with monocyte chemoattractant 
      protein-1 (MCP-1) in females. Due to the nature of the explorative study, the 
      studied markers alone did not indicate statistical significance for the 
      prediction of mental health problems. Our analysis provided new insight into 
      potential plasma-based biomarkers to predict mental health issues.
FAU - Alatalo, Arto
AU  - Alatalo A
AUID- ORCID: 0000-0002-7685-338X
AD  - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
FAU - de Sousa Maciel, Izaque
AU  - de Sousa Maciel I
AUID- ORCID: 0000-0001-6597-5288
AD  - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
FAU - Kucharikova, Nina
AU  - Kucharikova N
AUID- ORCID: 0000-0002-1921-774X
AD  - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
FAU - Chew, Sweelin
AU  - Chew S
AUID- ORCID: 0000-0001-9750-160X
AD  - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
FAU - van Kamp, Irene
AU  - van Kamp I
AUID- ORCID: 0000-0001-7977-1091
AD  - National Institute for Public Health and the Environment, 3721 MA Bilthoven, The 
      Netherlands.
FAU - Foraster, Maria
AU  - Foraster M
AD  - ISGlobal, 08036 Barcelona, Spain.
AD  - Universitat Pompeu Fabra (UPF), 08005 Barcelona, Spain.
AD  - CIBER Epidemiologia y Salud Publica (CIBEREsp), 28029 Madrid, Spain.
AD  - PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon 
      Llull (URL), 08025 Barcelona, Spain.
FAU - Julvez, Jordi
AU  - Julvez J
AUID- ORCID: 0000-0003-0818-4003
AD  - ISGlobal, 08036 Barcelona, Spain.
AD  - Clinical and Epidemiological Neuroscience Group (NeuroEpia), Institut d' 
      Investigacio Sanitaria Pere Virgili (IISPV), 43007 Reus, Spain.
FAU - Kanninen, Katja M
AU  - Kanninen KM
AUID- ORCID: 0000-0002-6717-8589
AD  - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
LA  - eng
GR  - 874724/European Union's Horizon 2020 Research and Innovation Program/
PT  - Journal Article
DEP - 20230307
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10045177
OTO - NOTNLM
OT  - adolescence
OT  - biomarkers
OT  - inflammation
OT  - mental health
OT  - mitochondrial DNA
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/03/07
CRDT- 2023/03/29 01:21
PHST- 2023/01/30 00:00 [received]
PHST- 2023/02/23 00:00 [revised]
PHST- 2023/03/05 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:21 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/07 00:00 [pmc-release]
AID - biomedicines11030818 [pii]
AID - biomedicines-11-00818 [pii]
AID - 10.3390/biomedicines11030818 [doi]
PST - epublish
SO  - Biomedicines. 2023 Mar 7;11(3):818. doi: 10.3390/biomedicines11030818.