PMID- 36980632
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 6
DP  - 2023 Mar 14
TI  - Long-Term Follow-Up of Bridging Therapies Prior to CAR T-Cell Therapy for 
      Relapsed/Refractory Large B Cell Lymphoma.
LID - 10.3390/cancers15061747 [doi]
LID - 1747
AB  - BACKGROUND: Bridging therapy (BT) with systemic therapy (ST), radiation therapy 
      (RT), or combined-modality therapy (CMT) is increasingly being utilized prior to 
      chimeric antigen receptor (CAR) T-cell therapy for large B-cell lymphoma (LBCL). 
      We report the long-term outcomes of the patients who received commercial CAR 
      T-cell therapy with or without BT. METHODS: The patients with LBCL who underwent 
      infusion of a commercial CD19 CAR T product were eligible. The radiation was 
      stratified as comprehensive or focal. The efficacy outcomes and toxicity were 
      analyzed. RESULTS: In total, 156 patients were included and, of them, 52.5% of 
      the patients received BT. The median progression-free survival (PFS) was 0.65 
      years in the BT cohort compared to 1.45 years in the non-BT cohort. The median 
      overall survival (OS) was 3.16 years in the BT cohort and was not reached in the 
      non-BT cohort. The patients who received comprehensive radiation (versus focal) 
      had significantly improved PFS and OS, achieving a 1-year PFS of 100% vs. 9.1% 
      and 1-year OS of 100% vs. 45.5%. There was no difference in the severe toxicity 
      between any of the nonbridging or BT cohorts. CONCLUSIONS: BT did not appear to 
      compromise outcomes with respect to response rates, disease control, survival, 
      and toxicity. The patients with limited disease treated with RT had favorable 
      outcomes.
FAU - Ladbury, Colton
AU  - Ladbury C
AUID- ORCID: 0000-0002-2668-3415
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Dandapani, Savita
AU  - Dandapani S
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Hao, Claire
AU  - Hao C
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Fabros, Mildred
AU  - Fabros M
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Amini, Arya
AU  - Amini A
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Sampath, Sagus
AU  - Sampath S
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Glaser, Scott
AU  - Glaser S
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Sokolov, Karen
AU  - Sokolov K
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Yeh, Jekwon
AU  - Yeh J
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA 91010, USA.
FAU - Baird, John H
AU  - Baird JH
AUID- ORCID: 0000-0001-8291-6546
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Kambhampati, Swetha
AU  - Kambhampati S
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Herrera, Alex
AU  - Herrera A
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Mei, Matthew
AU  - Mei M
AUID- ORCID: 0000-0002-1109-6955
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Nikolaenko, Liana
AU  - Nikolaenko L
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Shouse, Geoffrey
AU  - Shouse G
AUID- ORCID: 0000-0002-7917-5713
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
FAU - Budde, Lihua E
AU  - Budde LE
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope 
      National Medical Center, Duarte, CA 91010, USA.
LA  - eng
PT  - Journal Article
DEP - 20230314
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10046245
OTO - NOTNLM
OT  - bridging radiation
OT  - bridging therapy
OT  - chimeric antigen receptor T-cell (CAR T)
OT  - large B-cell lymphoma (LBCL)
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/03/14
CRDT- 2023/03/29 01:25
PHST- 2023/02/01 00:00 [received]
PHST- 2023/03/03 00:00 [revised]
PHST- 2023/03/10 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:25 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/14 00:00 [pmc-release]
AID - cancers15061747 [pii]
AID - cancers-15-01747 [pii]
AID - 10.3390/cancers15061747 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Mar 14;15(6):1747. doi: 10.3390/cancers15061747.