PMID- 36982617
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240123
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 6
DP  - 2023 Mar 14
TI  - Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 
      and Activating the PI3K-AKT Pathway.
LID - 10.3390/ijms24065544 [doi]
LID - 5544
AB  - Type 2 diabetes mellitus (T2DM), a chronic metabolic disease, is a public health 
      concern that seriously endangers human health. Sleeve gastrectomy (SG) can 
      relieve T2DM by improving glucose homeostasis and enhancing insulin sensitivity. 
      However, its specific underlying mechanism remains elusive. SG and sham surgery 
      were performed on mice fed a high-fat diet (HFD) for 16 weeks. Lipid metabolism 
      was evaluated via histology and serum lipid analysis. Glucose metabolism was 
      evaluated using the oral glucose tolerance test (OGTT) and insulin tolerance test 
      (ITT). Compared with the sham group, the SG group displayed a reduction in liver 
      lipid accumulation and glucose intolerance, and western blot analysis revealed 
      that the AMPK and PI3K-AKT pathways were activated. Furthermore, transcription 
      and translation levels of FBXO2 were reduced after SG. After liver-specific 
      overexpression of FBXO2, the improvement in glucose metabolism observed following 
      SG was blunted; however, the remission of fatty liver was not influenced by the 
      over expression of FBXO2. Our study explores the mechanism of SG in relieving 
      T2DM, indicating that FBXO2 is a noninvasive therapeutic target that warrants 
      further investigation.
FAU - Chen, Ningyuan
AU  - Chen N
AD  - Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
FAU - Cao, Ruican
AU  - Cao R
AD  - Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
FAU - Zhang, Zhao
AU  - Zhang Z
AUID- ORCID: 0000-0003-2206-8682
AD  - Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
FAU - Zhou, Sai
AU  - Zhou S
AD  - Graduate Faculty, Shandong First Medical University, Jinan 250117, China.
FAU - Hu, Sanyuan
AU  - Hu S
AD  - Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
LA  - eng
GR  - 82070869/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230314
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Blood Glucose)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (F-Box Proteins)
RN  - 0 (FBXO2 protein, human)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Lipids)
RN  - 0 (Nerve Tissue Proteins)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 0 (Fbx2 protein, mouse)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Blood Glucose/analysis
MH  - Cell Cycle Proteins/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - *F-Box Proteins
MH  - Gastrectomy
MH  - Glucose/metabolism
MH  - Lipids
MH  - Nerve Tissue Proteins/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
PMC - PMC10052132
OTO - NOTNLM
OT  - FBXO2
OT  - PI3K-AKT pathway
OT  - SG
OT  - T2DM
OT  - glucose metabolism
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:11
PMCR- 2023/03/14
CRDT- 2023/03/29 01:38
PHST- 2023/02/07 00:00 [received]
PHST- 2023/03/02 00:00 [revised]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/03/30 06:11 [medline]
PHST- 2023/03/29 01:38 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/14 00:00 [pmc-release]
AID - ijms24065544 [pii]
AID - ijms-24-05544 [pii]
AID - 10.3390/ijms24065544 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Mar 14;24(6):5544. doi: 10.3390/ijms24065544.