PMID- 36983305
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 6
DP  - 2023 Mar 16
TI  - Association of Chronic Heart Failure with Frailty, Malnutrition, and Sarcopenia 
      Parameters in Older Patients-A Cross-Sectional Study in a Geriatric Ward.
LID - 10.3390/jcm12062305 [doi]
LID - 2305
AB  - The need to assess sarcopenia and frailty in patients with chronic heart failure 
      (HF) has recently been raised. This cross-sectional study of 416 geriatric ward 
      patients (median age (Me)-82 (IQR, 77-86) years, 77.4% female, 96.9% community 
      dwelling) aimed to assess the prevalence of dynapenia, frailty syndrome, 
      functional and nutritional health, and co-morbidity regarding their HF status. We 
      collected data from comprehensive geriatric assessment. We observed HF in 162 
      (38.9%) patients, with 80 (49.4%) classified as New York Heart Association (NYHA) 
      class III or IV. HF patients were significantly older, more frequently male, 
      obese, hospitalized in the previous year, burdened with multimorbidity and 
      polypharmacy, classified as frail, dependent on daily living activities, and 
      physically non-active. Ischemic heart disease, atrial fibrillation, diabetes, 
      peripheral arterial disease, anemia, chronic kidney disease, history of 
      myocardial infarction, and stroke were found significantly more often in the HF 
      group. A considerably higher percentage of HF patients had dynapenia (54.9% 
      versus 41.9%, p = 0.02), but the difference was significant only in women. We 
      found no significant difference between HF and no-HF groups regarding muscle 
      performance, except for lower median gait speed in the HF group-0.53 m/s 
      (0.35-0.89 m/s) versus 0.68 m/s (0.44-0.99 m/s), p = 0.02). HF patients 
      significantly more often had low grip strength accompanied by slow gait, 
      suggesting probable severe sarcopenia (40.4% vs. 29% in patients without HF, p = 
      0.046). In the regression analysis, significantly higher odds for HF were 
      observed for lower mid-arm circumference (MAC) and dynapenia when controlling for 
      age, sex, body mass index (BMI), calf circumference (CC), peripheral arterial 
      disease, history of stroke, ischemic heart disease, atrial fibrillation, and 
      diabetes mellitus. Conclusions: HF geriatric patients are often burdened with 
      frailty, obesity, multimorbidity, and polypharmacy. As a result, they are more 
      likely to present low muscle strength (potential sarcopenia), which is frequently 
      accompanied by functional limitations (suggestive of more advanced stages of 
      sarcopenia). This tendency is evident mainly in older women. Nevertheless, 
      sarcopenia can be independently associated with HF in older patients with 
      multimorbidity and disability who are hospitalized in a geriatric department, as 
      a multivariable logistic regression analysis demonstrated.
FAU - Charkiewicz, Miroslaw
AU  - Charkiewicz M
AD  - Department of Cardiology, Hospital of the Ministry of Interior and Administration 
      in Bialystok, 15-471 Bialystok, Poland.
FAU - Wojszel, Zyta Beata
AU  - Wojszel ZB
AUID- ORCID: 0000-0002-6472-5241
AD  - Department of Geriatrics, Medical University of Bialystok, 15-471 Bialystok, 
      Poland.
AD  - Department of Geriatrics, Hospital of the Ministry of Interior and Administration 
      in Bialystok, 15-471 Bialystok, Poland.
FAU - Kasiukiewicz, Agnieszka
AU  - Kasiukiewicz A
AUID- ORCID: 0000-0003-0419-5709
AD  - Department of Geriatrics, Medical University of Bialystok, 15-471 Bialystok, 
      Poland.
AD  - Department of Geriatrics, Hospital of the Ministry of Interior and Administration 
      in Bialystok, 15-471 Bialystok, Poland.
FAU - Magnuszewski, Lukasz
AU  - Magnuszewski L
AUID- ORCID: 0000-0002-4679-1253
AD  - Department of Geriatrics, Medical University of Bialystok, 15-471 Bialystok, 
      Poland.
AD  - Doctoral Studies, Faculty of Health Sciences, Medical University of Bialystok, 
      15-471 Bialystok, Poland.
FAU - Wojszel, Aleksandra
AU  - Wojszel A
AD  - Interdisciplinary Student's Scientific Society at the Department of Geriatrics, 
      Faculty of Health Sciences, Medical University of Bialystok, 15-471 Bialystok, 
      Poland.
LA  - eng
GR  - SUB/1/DN/22/001/3301/Medical University of Bialystok Poland/
PT  - Journal Article
DEP - 20230316
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10052656
OTO - NOTNLM
OT  - comprehensive geriatric assessment
OT  - frailty
OT  - heart failure
OT  - malnutrition
OT  - multimorbidity
OT  - older adults
OT  - sarcopenia
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study, in the collection, analyses, or interpretation of data, in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/03/16
CRDT- 2023/03/29 01:43
PHST- 2023/02/11 00:00 [received]
PHST- 2023/03/10 00:00 [revised]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:43 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/16 00:00 [pmc-release]
AID - jcm12062305 [pii]
AID - jcm-12-02305 [pii]
AID - 10.3390/jcm12062305 [doi]
PST - epublish
SO  - J Clin Med. 2023 Mar 16;12(6):2305. doi: 10.3390/jcm12062305.