PMID- 36983998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 13
IP  - 3
DP  - 2023 Mar 21
TI  - Molecular Characteristics and Pathogenicity of Porcine Reproductive and 
      Respiratory Syndrome Virus (PRRSV) 1 in Taiwan during 2019-2020.
LID - 10.3390/life13030843 [doi]
LID - 843
AB  - Two variants of porcine reproductive and respiratory syndrome virus (PRRSV), 
      PRRSV 1 and PRRSV 2, have caused abortion in pregnant sows and respiratory 
      distress in nursery pigs worldwide. PRRSV 2 has been thoroughly researched in 
      Taiwan since 1993; however, the first case of PRRSV 1 was not reported until late 
      2018. To decipher the genetic characteristics of PRRSV 1 in Taiwan, open reading 
      frame 5 (ORF5) genes of PRRSV 1 strains collected from 11 individual pig farms in 
      2019-2020 were successfully sequenced. All Taiwanese ORF5 sequences were closely 
      related to Spanish-like PRRSV strains, which are considered to share a common 
      evolutionary origin with the strain used for the PRRSV 1 vaccine. Analyses of 
      amino acid (aa) and non-synonymous substitutions showed that genetic variations 
      resulted in numerously specific codon mutations scattered across the neutralizing 
      epitopes within the ORF5 gene. The PRRSV 1 challenge experiment disclosed the 
      pathogenetic capability of the NPUST2789 isolate in nursery pigs. These findings 
      provide comprehensive knowledge of the molecular diversity of the PRRSV 1 variant 
      in local Taiwanese fields and facilitate the development of suitable immunization 
      programs against this disease.
FAU - Hsueh, Fu-Chun
AU  - Hsueh FC
AUID- ORCID: 0000-0002-4319-6600
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Kuo, Kun-Lin
AU  - Kuo KL
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Hsu, Feng-Yang
AU  - Hsu FY
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Wang, Sheng-Yuan
AU  - Wang SY
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Chiu, Hsien-Jen
AU  - Chiu HJ
AUID- ORCID: 0009-0004-0624-7511
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Wu, Meng-Tien
AU  - Wu MT
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Lin, Chuen-Fu
AU  - Lin CF
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Huang, Yu-Han
AU  - Huang YH
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Chiou, Ming-Tang
AU  - Chiou MT
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
FAU - Lin, Chao-Nan
AU  - Lin CN
AUID- ORCID: 0000-0003-1911-7535
AD  - Animal Disease Diagnostic Center, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
LA  - eng
GR  - MOST110-2313-B-020-009-MY2/National Science and Technology Council/
PT  - Journal Article
DEP - 20230321
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC10056585
OTO - NOTNLM
OT  - PRRSV 1
OT  - Taiwan
OT  - challenge experiment
OT  - phylogenetic analysis
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:01
PMCR- 2023/03/21
CRDT- 2023/03/29 01:47
PHST- 2023/02/23 00:00 [received]
PHST- 2023/03/16 00:00 [revised]
PHST- 2023/03/19 00:00 [accepted]
PHST- 2023/03/30 06:01 [medline]
PHST- 2023/03/29 01:47 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/21 00:00 [pmc-release]
AID - life13030843 [pii]
AID - life-13-00843 [pii]
AID - 10.3390/life13030843 [doi]
PST - epublish
SO  - Life (Basel). 2023 Mar 21;13(3):843. doi: 10.3390/life13030843.