PMID- 36984520
OWN - NLM
STAT- MEDLINE
DCOM- 20230330
LR  - 20230331
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 3
DP  - 2023 Mar 7
TI  - Risk Factors for Emergency Department Presentations after the Initiation of 
      Opioid Analgesics in Non-Cancer Patients in Korea: A Nationwide Study.
LID - 10.3390/medicina59030519 [doi]
LID - 519
AB  - Background and Objectives: Opioid use in Korea is lower than in other developed 
      countries. However, recent studies have reported an increase in opioid 
      prescriptions and the number of chronic opioid users. The current status of 
      adverse events (AEs) associated with opioid analgesics in Korea is unclear. This 
      nested case-control study aimed to evaluate the influence of opioid analgesic use 
      patterns on all emergency department (ED) visits and opioid-related ED visits 
      after opioid analgesic initiation using the national claims database. Materials 
      and Methods: Adult non-cancer patients who initiated non-injectable opioid 
      analgesics (NIOA) between January 2017 and June 2018 were included. We defined 
      the case group as patients who visited the ED within six months of opioid 
      initiation, and the control group was selected in a 1:1 ratio using an exact 
      matching method. Results: A total of 97,735 patients (13.58%) visited the ED 
      within six months of NIOA initiation. Nearly 32% of cases were linked to 
      opioid-related AEs. The most frequent AEs were falls and fractures (61.27%). 
      After adjusting for covariates, opioid initiation at the ED was associated with 
      all-cause or opioid-related ED visits (adjusted odds ratio (aOR) = 3.19, 95% 
      confidence interval (CI) = 3.09-3.29; aOR = 3.82, 95% CI = 3.62-4.04, 
      respectively). Chronic NIOA use was associated with all-cause and opioid-related 
      ED visits (aOR = 1.32, 95% CI = 1.23-1.40; aOR = 1.56, 95% CI = 1.39-1.76, 
      respectively). Conclusion: This study found that 13% of non-cancer patients 
      visited the ED within six months of NIOA initiation. In addition, the NIOA use 
      pattern was significantly associated with all-cause and opioid-related ED visits.
FAU - Noh, Yoojin
AU  - Noh Y
AUID- ORCID: 0000-0001-9323-5092
AD  - Pharmacy School, Massachusetts College of Pharmacy and Health Sciences, 19 Foster 
      St., Worcester, MA 01608, USA.
FAU - Heo, Kyu-Nam
AU  - Heo KN
AUID- ORCID: 0000-0003-3626-3999
AD  - College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul 
      National University, Seoul 08826, Republic of Korea.
FAU - Kim, Dal-Ah
AU  - Kim DA
AD  - Department of Anesthesiology and Pain Medicine, Incheon St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Incheon 22711, Republic of 
      Korea.
FAU - Han, Ji-Min
AU  - Han JM
AD  - College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of 
      Korea.
FAU - Lee, Ju-Yeun
AU  - Lee JY
AUID- ORCID: 0000-0002-2261-7330
AD  - College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul 
      National University, Seoul 08826, Republic of Korea.
FAU - Ah, Young-Mi
AU  - Ah YM
AD  - College of Pharmacy, Yeungnam University, Gyeungsan 35841, Republic of Korea.
LA  - eng
GR  - 2019R1G1A1011055/National Research Foundation of Korea/
GR  - HI21C1389/Korea Health Industry Development Institute/Republic of Korea
PT  - Journal Article
DEP - 20230307
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Analgesics, Non-Narcotic)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Analgesics, Opioid/adverse effects
MH  - Case-Control Studies
MH  - Risk Factors
MH  - *Analgesics, Non-Narcotic
MH  - Emergency Service, Hospital
MH  - Republic of Korea/epidemiology
PMC - PMC10056559
OTO - NOTNLM
OT  - adverse drug events
OT  - emergency department
OT  - national claim database
OT  - opioid analgesics
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design, execution, interpretation, or writing of the study.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:11
PMCR- 2023/03/07
CRDT- 2023/03/29 01:50
PHST- 2023/01/07 00:00 [received]
PHST- 2023/02/23 00:00 [revised]
PHST- 2023/03/03 00:00 [accepted]
PHST- 2023/03/30 06:11 [medline]
PHST- 2023/03/29 01:50 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/07 00:00 [pmc-release]
AID - medicina59030519 [pii]
AID - medicina-59-00519 [pii]
AID - 10.3390/medicina59030519 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Mar 7;59(3):519. doi: 10.3390/medicina59030519.