PMID- 36984530
OWN - NLM
STAT- MEDLINE
DCOM- 20230330
LR  - 20230331
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 3
DP  - 2023 Mar 8
TI  - Correlation between Morphological Characteristics of Macular Edema and Visual 
      Acuity in Young Patients with Idiopathic Intermediate Uveitis.
LID - 10.3390/medicina59030529 [doi]
LID - 529
AB  - Background and Objectives: Macular edema (ME) is a common complication of 
      intermediate uveitis (IU). It is often responsible for a decrease in visual 
      acuity (VA). Three distinct patterns of macular edema have been described in 
      intermediate uveitis, namely, cystoid macular edema (CME), diffuse macular edema 
      (DME), and serous retinal detachment (SRD). The current study aims to describe 
      the characteristics of macular edema in young patients with idiopathic 
      intermediate uveitis and to correlate its features with VA using spectral domain 
      optical coherence tomography (SD-OCT). Materials and Methods: A total of 27 eyes 
      from 18 patients with idiopathic IU complicated by ME were included in this 
      retrospective study. All patients underwent SD-OCT; data were gathered at the 
      onset of ME. Best-corrected VA (BCVA) was correlated with the morphological 
      features of ME. Results: BCVA was negatively correlated with Ellipsoid Zone (EZ) 
      disruption (p = 0.00021), cystoid pattern (p = 0.00021), central subfield 
      thickness (CST) (p < 0.001), and serous retinal detachment (0.037). Conclusions: 
      In ME secondary to idiopathic IU, VA negatively correlates with Ellipsoid Zone 
      disruption and increases in CST. Moreover, vision is influenced by the presence 
      of cysts in the inner nuclear and outer nuclear layers and by the neuroepithelium 
      detachment.
FAU - Iannetti, Ludovico
AU  - Iannetti L
AUID- ORCID: 0000-0003-1790-3532
AD  - Ophthalmology Unit, Head and Neck Department, Policlinico Umberto I University 
      Hospital, Sapienza University of Rome, 00161 Rome, Italy.
FAU - Scarinci, Fabio
AU  - Scarinci F
AUID- ORCID: 0000-0001-5444-4377
AD  - IRCCS Fondazione Bietti, 00199 Rome, Italy.
FAU - Alisi, Ludovico
AU  - Alisi L
AUID- ORCID: 0000-0001-5366-882X
AD  - Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Armentano, Marta
AU  - Armentano M
AD  - Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Sampalmieri, Lorenzo
AU  - Sampalmieri L
AD  - Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
FAU - La Cava, Maurizio
AU  - La Cava M
AD  - Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Gharbiya, Magda
AU  - Gharbiya M
AUID- ORCID: 0000-0002-4991-9689
AD  - Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230308
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - *Macular Edema/etiology
MH  - *Retinal Detachment/complications
MH  - Retrospective Studies
MH  - *Uveitis, Intermediate/complications
MH  - Visual Acuity
MH  - Tomography, Optical Coherence/methods
PMC - PMC10054752
OTO - NOTNLM
OT  - intermediate uveitis
OT  - macular edema
OT  - optical coherence tomography
OT  - retinal morphology
OT  - visual acuity
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/30 06:11
PMCR- 2023/03/08
CRDT- 2023/03/29 01:50
PHST- 2023/01/01 00:00 [received]
PHST- 2023/02/12 00:00 [revised]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/03/30 06:11 [medline]
PHST- 2023/03/29 01:50 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/08 00:00 [pmc-release]
AID - medicina59030529 [pii]
AID - medicina-59-00529 [pii]
AID - 10.3390/medicina59030529 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Mar 8;59(3):529. doi: 10.3390/medicina59030529.