PMID- 36986038 OWN - NLM STAT- MEDLINE DCOM- 20230330 LR - 20230331 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 15 IP - 6 DP - 2023 Mar 7 TI - Effects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet. LID - 10.3390/nu15061308 [doi] LID - 1308 AB - The study of medicinal plants, such as the genus Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of G. gardneriana at doses of 200 or 400 mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of 200 mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). In addition, hepatic steatosis and microvesicular steatosis were indicated. It was revealed that, under the experimental conditions in the study, G. gardneriana did not prevent weight gain or comorbidities; that is, a different behavior was obtained from that described in the literature with regard to the medicinal potential of the Garcinia species, which is probably related to the phytochemical properties. FAU - Santo, Bruna Larissa Spontoni do Espirito AU - Santo BLSDE AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Santana, Lidiani Figueiredo AU - Santana LF AUID- ORCID: 0000-0001-9171-4698 AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Kato Junior, Wilson Hino AU - Kato Junior WH AD - Graduate of Pharmaceutical Sciences, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Araujo, Felipe de Oliveira de AU - Araujo FO AD - Graduate of Electrical Engineering, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Tatara, Mariana Bento AU - Tatara MB AD - Health Science Research Laboratory, Federal University of Grande Dourados, Dourados 79804-970, Brazil. FAU - Croda, Julio AU - Croda J AD - School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil. AD - Oswaldo Cruz Foundation, Campo Grande 79074-460, Brazil. FAU - Bogo, Danielle AU - Bogo D AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Freitas, Karine de Cassia AU - Freitas KC AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Guimaraes, Rita de Cassia Avellaneda AU - Guimaraes RCA AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Hiane, Priscila Aiko AU - Hiane PA AUID- ORCID: 0000-0003-1115-4083 AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Pott, Arnildo AU - Pott A AUID- ORCID: 0000-0002-8599-9276 AD - Laboratory of Botany, Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil. FAU - Filiu, Wander Fernando de Oliveira AU - Filiu WFO AD - Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - Faria, Bernardo Bacelar de AU - Faria BB AD - Diagnostic Medicine Laboratory-Scapulatempo, Campo Grande 79002-17, Brazil. FAU - Figueiredo, Patricia de Oliveira AU - Figueiredo PO AD - Laboratory of Pronabio (Bioactive Natural Products), Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. FAU - do Nascimento, Valter Aragao AU - do Nascimento VA AUID- ORCID: 0000-0002-9020-8002 AD - Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil. FAU - Ayres, Frederico Louveira AU - Ayres FL AD - Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil. FAU - Bastos, Paulo Roberto Haidamus de Oliveira AU - Bastos PRHO AD - Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20230307 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Plant Extracts) RN - 3K9958V90M (Ethanol) RN - 059QF0KO0R (Water) SB - IM MH - Mice MH - Animals MH - *Garcinia/chemistry MH - Plant Extracts/pharmacology MH - Ethanol MH - *Plants, Medicinal MH - *Fatty Liver MH - Water MH - Diet, High-Fat/adverse effects PMC - PMC10051817 OTO - NOTNLM OT - Brazilian plant OT - bacupari OT - medicinal plant OT - metabolic changes COIS- The authors declare no conflict of interest. EDAT- 2023/03/30 06:00 MHDA- 2023/03/30 06:11 PMCR- 2023/03/07 CRDT- 2023/03/29 01:59 PHST- 2022/12/08 00:00 [received] PHST- 2023/02/05 00:00 [revised] PHST- 2023/02/07 00:00 [accepted] PHST- 2023/03/30 06:11 [medline] PHST- 2023/03/29 01:59 [entrez] PHST- 2023/03/30 06:00 [pubmed] PHST- 2023/03/07 00:00 [pmc-release] AID - nu15061308 [pii] AID - nutrients-15-01308 [pii] AID - 10.3390/nu15061308 [doi] PST - epublish SO - Nutrients. 2023 Mar 7;15(6):1308. doi: 10.3390/nu15061308.