PMID- 36987580
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20230608
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 103
IP  - 10
DP  - 2023 Aug 15
TI  - Fructo-oligofructose ameliorates 2,4-dinitrofluorobenzene-induced atopic 
      dermatitis-like skin lesions and psychiatric comorbidities in mice.
PG  - 5004-5018
LID - 10.1002/jsfa.12582 [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder 
      characterized by pruritus and eczema lesions and psychiatric comorbidities. The 
      gut-brain-skin axis plays a pivotal role during AD development, which might 
      suggest a novel therapeutic strategy for AD. The present study aims to uncover 
      the protective effects and underlying mechanisms of fructo-oligofructose (FOS), a 
      type of prebiotic, on AD-like skin manifestations and comorbid anxiety and 
      depression in AD mice. RESULTS: Female Kunming mice were treated topically with 
      2,4-dinitrofluorobenzene (DNFB) to induce AD-like symptoms and FOS was 
      administered daily for 14 days. The results showed that FOS could alleviate 
      AD-like skin lesions markedly as evidenced by dramatic decreases in severity 
      score, scratching bouts, the levels of immunoglobulin E (IgE) and T helper 
      1(Th1)/Th2-related cytokines, and the infiltration of inflammatory cells and mast 
      cells to the dermal tissues. The comorbid anxiety and depressive-like behaviors, 
      estimated by the forced swimming test (FST), the tail-suspension test (TST), the 
      open-field test (OFT), and the zero maze test (ZMT) in AD mice, were 
      significantly attenuated by FOS. Fructo-oligofructose significantly upregulated 
      brain neurotransmitters levels of 5-hydroxytryptamine (5-HT) and dopamine (DA). 
      Furthermore, FOS treatment increased the relative abundance of gut microbiota, 
      such as Prevotella and Lactobacillus and the concentrations of short-chain fatty 
      acids (SCFAs), especially acetate and iso-butyrate in the feces of AD mice. The 
      correlation analysis indicated that the reshaped gut microbiome composition and 
      enhanced SCFAs formation are associated with skin inflammation and behavioral 
      alteration. CONCLUSION: Collectively, these data identify FOS as a promising 
      microbiota-targeted treatment for AD-like skin inflammation and comorbid anxiety 
      and depressive-like behaviors. (c) 2023 Society of Chemical Industry.
CI  - (c) 2023 Society of Chemical Industry.
FAU - Chen, Shaoze
AU  - Chen S
AUID- ORCID: 0000-0001-9174-6737
AD  - School of Medicine, Jianghan University, Wuhan, China.
FAU - Tang, Liu
AU  - Tang L
AUID- ORCID: 0000-0003-1599-7061
AD  - Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Nie, Tingting
AU  - Nie T
AD  - School of Medicine, Jianghan University, Wuhan, China.
FAU - Fang, Mingyu
AU  - Fang M
AD  - School of Medicine, Jianghan University, Wuhan, China.
FAU - Cao, Xiaoqin
AU  - Cao X
AD  - School of Medicine, Jianghan University, Wuhan, China.
LA  - eng
GR  - 08210154/the Jianghan University 2021 University Research Program/
GR  - 2042022kf1077/the Fundamental Research Funds for the Central Universities/
PT  - Journal Article
DEP - 20230412
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - D241E059U6 (Dinitrofluorobenzene)
RN  - 0 (oligofructose)
RN  - 0 (Cytokines)
RN  - Kunming mice
SB  - IM
MH  - Mice
MH  - Female
MH  - Animals
MH  - *Dermatitis, Atopic/chemically induced/drug therapy/pathology
MH  - Dinitrofluorobenzene/adverse effects
MH  - Skin
MH  - Cytokines
MH  - Inflammation/drug therapy
OTO - NOTNLM
OT  - atopic dermatitis
OT  - fructo-oligosaccharide
OT  - gut microbiota
OT  - gut-brain-skin axis
OT  - short-chain fatty acids
EDAT- 2023/03/30 06:00
MHDA- 2023/06/08 06:42
CRDT- 2023/03/29 02:42
PHST- 2023/03/14 00:00 [revised]
PHST- 2022/07/18 00:00 [received]
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 02:42 [entrez]
AID - 10.1002/jsfa.12582 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2023 Aug 15;103(10):5004-5018. doi: 10.1002/jsfa.12582. Epub 
      2023 Apr 12.