PMID- 36987923
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20231020
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 80
IP  - 6
DP  - 2023 Jun
TI  - Associations of Urine Biomarkers of Kidney Tubule Health With Incident 
      Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The 
      CARDIA Study.
PG  - 1353-1362
LID - 10.1161/HYPERTENSIONAHA.123.21084 [doi]
AB  - BACKGROUND: Urine biomarkers of kidney tubule injury associate with incident 
      hypertension in older adults with comorbidities, but less is known about these 
      associations in younger adults. METHODS: In 1170 participants of the CARDIA study 
      (Coronary Artery Risk Development in Young Adults; mean age, 45 years; 40% Black 
      people; 56% women) without hypertension, cardiovascular disease, or kidney 
      disease at baseline, we examined associations of urine MCP-1 (monocyte 
      chemoattractant protein-1), alpha1m (alpha-1-microglobulin), KIM-1 (kidney injury 
      molecule-1), EGF (epidermal growth factor), IL (interleukin)-18, YKL-40 
      (chitinase-3-like protein 1), and UMOD (uromodulin) with incident hypertension 
      (onset of systolic blood pressure [BP] >/=130 mm Hg or diastolic BP >/=80 mm Hg or 
      initiation of hypertension medications) and longitudinal BP change in models 
      adjusted for hypertension risk factors, estimated glomerular filtration rate, and 
      albuminuria. RESULTS: After a median 9.9 (interquartile range, 5.9-10.2) years, 
      376 participants developed incident hypertension. In demographic-adjusted 
      analyses, higher tertiles of EGF associated with lower risk of incident 
      hypertension in both Black and White participants. After multivariable 
      adjustment, the risk of incident hypertension remained lower in tertile 2 (hazard 
      ratio, 0.70 [95% CI, 0.50-0.97]) and tertile 3 (hazard ratio, 0.58 [0.39-0.85]) 
      of EGF versus tertile 1. In fully adjusted models, participants in EGF tertile 3 
      had smaller 10-year increases in systolic (-3.4 [95% CI, -6.1 to -0.7] mm Hg) and 
      diastolic BP (-2.6 [95% CI, -4.6 to -0.6] mm Hg) than tertile 1. Other biomarkers 
      showed inconsistent associations with incident hypertension and BP change. 
      CONCLUSIONS: In middle-aged adults without hypertension, cardiovascular disease, 
      or kidney disease, higher urine EGF associated with lower risk of incident 
      hypertension and lower 10-year BP elevations.
FAU - Khan, Muhammad B
AU  - Khan MB
AD  - Departments of Medicine (M.B.K., O.M.G.), University of Alabama at Birmingham.
FAU - Scherzer, Rebecca
AU  - Scherzer R
AUID- ORCID: 0000-0002-1579-5390
AD  - Kidney Health Research Collaborative, San Francisco Veterans Affairs Health Care 
      System (R.S., M.G.S.), University of California.
FAU - Lewis, Cora E
AU  - Lewis CE
AUID- ORCID: 0000-0002-2301-5796
AD  - Epidemiology (C.E.L., O.M.G.), University of Alabama at Birmingham.
FAU - Malhotra, Rakesh
AU  - Malhotra R
AD  - Division of Nephrology-Hypertension (R.M., J.H.I.), University of California.
AD  - Nephrology Section Veterans Affairs San Diego Healthcare System, CA (R.M., 
      J.H.I.).
FAU - Ix, Joachim H
AU  - Ix JH
AD  - Division of Nephrology-Hypertension (R.M., J.H.I.), University of California.
AD  - Nephrology Section Veterans Affairs San Diego Healthcare System, CA (R.M., 
      J.H.I.).
FAU - Shlipak, Michael G
AU  - Shlipak MG
AUID- ORCID: 0000-0002-9559-204X
AD  - Kidney Health Research Collaborative, San Francisco Veterans Affairs Health Care 
      System (R.S., M.G.S.), University of California.
AD  - Department of Medicine, San Francisco Veterans Affairs Health Care System, CA 
      (M.G.S.).
FAU - Gutierrez, Orlando M
AU  - Gutierrez OM
AUID- ORCID: 0000-0001-6593-3571
AD  - Departments of Medicine (M.B.K., O.M.G.), University of Alabama at Birmingham.
AD  - Epidemiology (C.E.L., O.M.G.), University of Alabama at Birmingham.
LA  - eng
GR  - K23 DK132680/DK/NIDDK NIH HHS/United States
GR  - K24 DK116180/DK/NIDDK NIH HHS/United States
GR  - P30 DK079337/DK/NIDDK NIH HHS/United States
GR  - T32 DK007545/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230329
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Middle Aged
MH  - Young Adult
MH  - Humans
MH  - Female
MH  - Aged
MH  - Male
MH  - *Cardiovascular Diseases
MH  - Blood Pressure/physiology
MH  - Epidermal Growth Factor/therapeutic use
MH  - *Hypertension/diagnosis/epidemiology/complications
MH  - Risk Factors
MH  - Kidney Tubules
MH  - *Kidney Diseases
MH  - *Hypotension
MH  - Biomarkers
MH  - Glomerular Filtration Rate
PMC - PMC10192098
MID - NIHMS1884068
OTO - NOTNLM
OT  - biomarkers
OT  - blood pressure
OT  - cardiovascular diseases
OT  - hypertension
OT  - kidney diseases
COIS- Disclosures O.M. Gutierrez reports receiving grant funding and honoraria from 
      Akebia and Amgen; grant funding from GlaxoSmithKline; honoraria from AstraZeneca, 
      Reata, and Ardelyx; and serving on a Data Monitoring Committee for QED. The other 
      authors report no conflicts.
EDAT- 2023/03/30 06:00
MHDA- 2023/05/19 06:42
PMCR- 2024/06/01
CRDT- 2023/03/29 05:03
PHST- 2024/06/01 00:00 [pmc-release]
PHST- 2023/05/19 06:42 [medline]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 05:03 [entrez]
AID - 10.1161/HYPERTENSIONAHA.123.21084 [doi]
PST - ppublish
SO  - Hypertension. 2023 Jun;80(6):1353-1362. doi: 10.1161/HYPERTENSIONAHA.123.21084. 
      Epub 2023 Mar 29.