PMID- 36988307
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230403
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 51
IP  - 3
DP  - 2023 Mar
TI  - Clinical factors affecting the long-term survival of breast cancer patients.
PG  - 3000605231164004
LID - 10.1177/03000605231164004 [doi]
LID - 03000605231164004
AB  - OBJECTIVE: The average 5-year survival rate of breast cancer (BC) patients has 
      been significantly prolonged with new therapeutic methods. However, their effects 
      on BC patient long-term survival rates are unclear. Therefore, this study aimed 
      to analyze the specific clinical factors that can affect BC long-term survival. 
      METHODS: Here, we conducted a retrospective study and analyzed long-term survival 
      using data of 3,240 BC patients from 1977 to 2005 from the Genotype-Tissue 
      Expression (GTEx) database using the Kaplan-Meier method. RESULTS: Breast tumor 
      size and stage were negatively correlated with long-term survival, but age showed 
      no significant correlation. Estrogen receptor (ER) and progesterone receptor (PR) 
      expression were each positively correlated with patient survival time, while 
      ERBB2 receptor (HER2) expression was negatively correlated with survival time. 
      Patients with high Nottingham prognostic index (NPI) values did not benefit from 
      available therapies. Furthermore, breast-conserving surgery is more conducive to 
      BC patient long-term survival than mastectomy. CONCLUSIONS: Early detection and 
      breast-conserving surgery may support long-term survival for BC patients. 
      Elevated expression of ER and PR were both associated with longer patient 
      survival time, while positive expression of HER2 showed the opposite trend. The 
      long-term survival rates of patients with high NPI values can potentially be 
      increased.
FAU - Li, Yong-Hui
AU  - Li YH
AD  - Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 
      Shanghai, China.
AD  - Luoyang Normal University, Henan, China.
FAU - Wang, Xiao-Ying
AU  - Wang XY
AUID- ORCID: 0000-0001-9850-7800
AD  - Shanghai University of Traditional Chinese Medicine, Shanghai, China.
FAU - Shen, Jun-Wei
AU  - Shen JW
AD  - Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 
      Shanghai, China.
FAU - Ma, Lin-Lin
AU  - Ma LL
AD  - Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 
      Shanghai, China.
FAU - Wang, Cui-Ping
AU  - Wang CP
AD  - Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 
      Shanghai, China.
FAU - He, Kai
AU  - He K
AD  - Shanghai University of Traditional Chinese Medicine, Shanghai, China.
FAU - Liu, Ding-Sheng
AU  - Liu DS
AD  - Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
FAU - Li, Yan-Fei
AU  - Li YF
AD  - Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/genetics/surgery/metabolism
MH  - Biomarkers, Tumor
MH  - Retrospective Studies
MH  - Mastectomy
MH  - Receptor, ErbB-2/genetics/metabolism
MH  - Receptors, Estrogen/genetics/metabolism
MH  - Receptors, Progesterone/genetics/metabolism
MH  - Prognosis
PMC - PMC10064465
OTO - NOTNLM
OT  - Breast cancer
OT  - Nottingham prognostic index
OT  - breast-conserving surgery
OT  - estrogen receptor
OT  - long-term survival
OT  - progesterone receptor
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/31 06:42
PMCR- 2023/03/29
CRDT- 2023/03/29 08:53
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/03/29 08:53 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - 10.1177_03000605231164004 [pii]
AID - 10.1177/03000605231164004 [doi]
PST - ppublish
SO  - J Int Med Res. 2023 Mar;51(3):3000605231164004. doi: 10.1177/03000605231164004.