PMID- 36988333
OWN - NLM
STAT- MEDLINE
DCOM- 20240228
LR  - 20240228
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 34
IP  - 2
DP  - 2024 Feb 26
TI  - Predictors of damage accrual in patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis: A nationwide prospective study.
PG  - 382-390
LID - 10.1093/mr/road029 [doi]
AB  - OBJECTIVES: This study elucidated the prognosis and risk factors associated with 
      damage accrual during long-term remission maintenance therapy for patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: We 
      obtained data from 120 patients registered in a nationwide prospective cohort 
      study on remission induction therapy in Japanese patients with AAV and rapidly 
      progressive glomerulonephritis (RemIT-JAV-RPGN), who achieved remission at 
      24 months after treatment initiation and were followed up for additional 
      24 months. The primary outcome was the vasculitis damage index (VDI) score at 
      Month 48, and the secondary outcome included risk factors associated with 
      increased total VDI at Month 48. RESULTS: The understudied patients comprised 52 
      men and 68 women aged 68 +/- 13 years. Between Months 25 and 48, the patients' 
      survival rate was 95% (114/120). End-stage renal disease developed in seven 
      patients by Month 48, and 64 cases had increased VDI. The multivariable analysis 
      results revealed that oral prednisolone (PSL) doses at Month 24 were associated 
      with damage accrual between Months 24 and 48. CONCLUSIONS: VDI accrual was 
      observed in more than half of patients with AAV during maintenance therapy, and 
      increased VDI scores were associated with oral PSL doses 24 months after 
      initiating remission induction therapy in Japan.
CI  - (c) Japan College of Rheumatology 2023. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Hara, Akinori
AU  - Hara A
AUID- ORCID: 0000-0002-0399-1474
AD  - Department of Hygiene and Public Health, Faculty of Medicine, Institute of 
      Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, 
      Japan.
FAU - Sada, Ken-Ei
AU  - Sada KE
AD  - Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama 
      University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 
      Okayama, Japan.
FAU - Wada, Takashi
AU  - Wada T
AD  - Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute 
      of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, 
      Japan.
FAU - Amano, Koichi
AU  - Amano K
AD  - Department of Rheumatology and Clinical Immunology, Saitama Medical Center, 
      Saitama Medical University, Kawagoe, Japan.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Atsumi, Tatsuya
AU  - Atsumi T
AD  - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine 
      and, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
FAU - Sugihara, Takahiko
AU  - Sugihara T
AD  - Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, 
      Tokyo, Japan.
FAU - Hirayama, Kouichi
AU  - Hirayama K
AD  - Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, 
      Japan.
FAU - Banno, Shogo
AU  - Banno S
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, 
      Japan.
FAU - Murakawa, Yohko
AU  - Murakawa Y
AD  - Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan.
FAU - Hasegawa, Midori
AU  - Hasegawa M
AD  - Department of Nephrology, Fujita Health University School of Medicine, Toyoake, 
      Japan.
FAU - Yamagata, Kunihiro
AU  - Yamagata K
AD  - Department of Nephrology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
FAU - Arimura, Yoshihiro
AU  - Arimura Y
AD  - Department of Nephrology and Rheumatology, Kyorin University School of Medicine, 
      Tokyo, Japan.
AD  - Kichijoji Asahi Hospital, Tokyo, Japan.
FAU - Makino, Hirofumi
AU  - Makino H
AD  - Okayama University, Okayama, Japan.
FAU - Harigai, Masayoshi
AU  - Harigai M
AD  - Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical 
      University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Prospective Studies
MH  - *Antibodies, Antineutrophil Cytoplasmic
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
MH  - Prednisolone/therapeutic use
MH  - Prognosis
MH  - Remission Induction
OTO - NOTNLM
OT  - ANCA
OT  - chronic damages
OT  - glucocorticoid
OT  - outcomes
OT  - remission maintenance
EDAT- 2023/03/30 06:00
MHDA- 2024/02/28 06:43
CRDT- 2023/03/29 09:04
PHST- 2022/09/22 00:00 [received]
PHST- 2023/03/13 00:00 [accepted]
PHST- 2024/02/28 06:43 [medline]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 09:04 [entrez]
AID - 7093075 [pii]
AID - 10.1093/mr/road029 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2024 Feb 26;34(2):382-390. doi: 10.1093/mr/road029.