PMID- 36989310
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230419
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 3
DP  - 2023
TI  - Distinctive serum lipidomic profile of IVIG-resistant Kawasaki disease children 
      before and after treatment.
PG  - e0283710
LID - 10.1371/journal.pone.0283710 [doi]
LID - e0283710
AB  - Kawasaki Disease (KD) is an acute inflammatory disorder associated with systemic 
      vasculitis. Intravenous immunoglobulin (IVIG) is an effective therapy for KD, 
      yet, about 20% of cases show IVIG resistance with persistent inflammation. The 
      lipid profile in IVIG-resistant KD patients and the relationship between lipid 
      characteristics and IVIG resistance remain unknown. In this study, serum samples 
      from twenty KD patients with different IVIG responses (sensitive, intermediate, 
      or resistant) were collected both before and after treatment, and lipidomic 
      analysis was performed using high-performance liquid chromatography-mass 
      spectrometry. As a result, before treatment, six lipid species were found as the 
      most variant features, in which all the top decreased lipids in the 
      IVIG-resistant group were lysophosphatidylcholine (LPC) and 
      lysophosphatidylethanolamine (LPE), suggesting the potential to be IVIG-resistant 
      markers in pretreatment diagnosis. During treatment, lipidomic changes showed a 
      weaker response in the IVIG-resistant group. After treatment, LPC and LPE species 
      exhibited lower in the IVIG-resistant group and negative correlation with the 
      inflammatory markers, indicating that the unique metabolism may occur among 
      IVIG-responsiveness. These results might contribute to diagnosing IVIG-resistant 
      patients more accurately for alternative therapy and to a better understanding of 
      how lipid metabolism is associated with IVIG sensitiveness/resistance in KD.
CI  - Copyright: (c) 2023 Chen et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Chen, Zhen
AU  - Chen Z
AUID- ORCID: 0000-0001-5339-2499
AD  - School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China.
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
FAU - Sai, Shuji
AU  - Sai S
AD  - Department of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Hokkaido, Japan.
AD  - Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
FAU - Nagumo, Kiyoshi
AU  - Nagumo K
AD  - Department of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Hokkaido, Japan.
FAU - Wu, Yue
AU  - Wu Y
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
FAU - Chiba, Hitoshi
AU  - Chiba H
AD  - Department of Nutrition, Sapporo University of Health Sciences, Sapporo, 
      Hokkaido, Japan.
FAU - Hui, Shu-Ping
AU  - Hui SP
AUID- ORCID: 0000-0001-9973-6461
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230329
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - Child
MH  - Infant
MH  - *Mucocutaneous Lymph Node Syndrome/complications
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Lipidomics
MH  - Lipids
MH  - Retrospective Studies
PMC - PMC10057782
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/31 06:42
PMCR- 2023/03/29
CRDT- 2023/03/29 13:44
PHST- 2022/07/12 00:00 [received]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/03/29 13:44 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - PONE-D-22-19611 [pii]
AID - 10.1371/journal.pone.0283710 [doi]
PST - epublish
SO  - PLoS One. 2023 Mar 29;18(3):e0283710. doi: 10.1371/journal.pone.0283710. 
      eCollection 2023.