PMID- 36989560
OWN - NLM
STAT- MEDLINE
DCOM- 20230919
LR  - 20230919
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 256
DP  - 2023 May
TI  - The associations between concentrations of gestational bisphenol analogues and 
      thyroid related hormones in cord blood: A prospective cohort study.
PG  - 114838
LID - S0147-6513(23)00342-1 [pii]
LID - 10.1016/j.ecoenv.2023.114838 [doi]
AB  - Animal studies indicated that Bisphenol analogues (BPs) exhibited potential 
      thyroid toxicity. However, little is known of the associations between maternal 
      BPs exposure and offspring's thyroid related hormones in humans. On the basis of 
      Shanghai-Minhang Birth Cohort study, we analyzed BPs in maternal urine collected 
      at the third trimester of pregnancy. Thyroid related hormones (THs), including 
      total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4), 
      free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were measured in cord 
      blood samples. We performed multiple linear regression and Bayesian kernel 
      machine regression (BKMR) models to explore the single and joint effects of 
      gestational BPs exposure on thyroid related hormones in cord blood among 258 
      mother-child pairs. Statistically significant inverse associations of categorized 
      BPA with FT3 and TT4 concentrations were observed. We also found a significant 
      association between the mixture of BPs in maternal urine and increased 
      concentration of TT3 in cord blood and a marginally significant association 
      between BPs mixture and increased FT3 concentrations. Further associations of BPA 
      with lower TT4/FT4 and of Bisphenol AF (BPAF) with higher TT3/FT3 were also 
      suggestive, by BKMR model, when other BPs were fixed at 25th percentiles. It was 
      concluded that prenatal BPs exposure was associated with THs in cord blood. 
      Exposure to BPA and BPAF might have large contributions to the effects on thyroid 
      function than other bisphenols.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Xi, Jianya
AU  - Xi J
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
FAU - Su, Xiujuan
AU  - Su X
AD  - Clinical Research center, Shanghai Key Laboratory of Maternal Fetal Medicine, 
      Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai 
      First Maternity and Infant Hospital, School of Medicine, Tongji University, 
      Shanghai 200092, China.
FAU - Wang, Ziliang
AU  - Wang Z
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
FAU - Ji, Honglei
AU  - Ji H
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
FAU - Liu, Xiaofang
AU  - Liu X
AD  - National Reference Laboratory of Dioxin, Institute of Health Inspection and 
      Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial 
      Center for Disease Control and Prevention, #35 Zhuo Daoquan North Road, Wuhan 
      430079, China.
FAU - Miao, Maohua
AU  - Miao M
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
FAU - Liang, Hong
AU  - Liang H
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China. 
      Electronic address: lucylhcn@163.com.
FAU - Yuan, Wei
AU  - Yuan W
AD  - NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, 779 Old Humin Road, Shanghai 200237, China.
LA  - eng
PT  - Journal Article
DEP - 20230328
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - OH7IX8A37J (4,4'-hexafluorisopropylidene diphenol)
RN  - 0 (Thyroid Hormones)
RN  - Q51BO43MG4 (Thyroxine)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Bayes Theorem
MH  - China
MH  - Cohort Studies
MH  - Fetal Blood/metabolism
MH  - Prospective Studies
MH  - Thyroid Gland
MH  - *Thyroid Hormones/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - *Environmental Exposure
OTO - NOTNLM
OT  - Bisphenol analogues
OT  - Cord blood
OT  - Gestational exposure
OT  - Prospective cohort study
OT  - Thyroid hormones
COIS- Declaration of Competing Interest There is no conflict of interest to declare. 
      The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/03/30 06:00
MHDA- 2023/04/26 06:41
CRDT- 2023/03/29 18:00
PHST- 2022/12/14 00:00 [received]
PHST- 2023/03/21 00:00 [revised]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/04/26 06:41 [medline]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 18:00 [entrez]
AID - S0147-6513(23)00342-1 [pii]
AID - 10.1016/j.ecoenv.2023.114838 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 May;256:114838. doi: 10.1016/j.ecoenv.2023.114838. 
      Epub 2023 Mar 28.