PMID- 36990072
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230623
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 20
IP  - 2
DP  - 2023 Mar-Apr
TI  - High serum Bhlhe40 levels are associated with subclinical atherosclerosis in 
      patients with type 2 diabetes mellitus: A cross-sectional study.
PG  - 14791641231169246
LID - 10.1177/14791641231169246 [doi]
LID - 14791641231169246
AB  - BACKGROUND: Our previous studies have shown that the basic helix-loop-helix 
      family member e40 (Bhlhe40) plays a critical role in regulating calcification and 
      senescence of vascular smooth muscle cells induced by high glucose. In this 
      study, we determined the association between serum Bhlhe40 levels and subclinical 
      atherosclerosis in patients with type 2 diabetes mellitus (T2DM). METHODS: 247 
      patients with T2DM were included in this cross-sectional study between June 2021 
      and July 2022. The presence of subclinical atherosclerosis was evaluated by 
      carotid ultrasonography. Serum Bhlhe40 concentrations were measured with an ELISA 
      kit. RESULTS: Serum Bhlhe40 levels were remarkably higher in the subclinical 
      atherosclerosis group than in the subjects without subclinical atherosclerosis (p 
      < 0.001). Correlation analysis showed a positive correlation between serum 
      Bhlhe40 and carotid intima-media thickness (C-IMT) (r = 0.155, p = 0.015). The 
      optimal threshold of serum Bhlhe40 > 5.67 ng/mL had an area under the ROC curve 
      (AUC) was 0.709 (p < 0.001). In addition, serum Bhlhe40 levels were associated 
      with the prevalence of subclinical atherosclerosis (OR: 1.790, 95% CI: 
      1.414-2.266, p < 0.001). CONCLUSION: Serum Bhlhe40 levels were significantly 
      higher in T2DM subjects with subclinical atherosclerosis and positively 
      associated with C-IMT.
FAU - Xu, Hui
AU  - Xu H
AD  - Department of Geriatrics, 619959The Second Xiangya Hospital of Central South 
      University, Changsha, China.
AD  - Institute of Aging and Age-related Disease Research, Central South University, 
      Changsha, China.
FAU - Xiang, Qun-Yan
AU  - Xiang QY
AD  - Department of Geriatrics, 619959The Second Xiangya Hospital of Central South 
      University, Changsha, China.
AD  - Institute of Aging and Age-related Disease Research, Central South University, 
      Changsha, China.
FAU - Li, Shuang
AU  - Li S
AUID- ORCID: 0000-0001-8857-724X
AD  - Department of Geriatrics, 619959The Second Xiangya Hospital of Central South 
      University, Changsha, China.
AD  - Institute of Aging and Age-related Disease Research, Central South University, 
      Changsha, China.
FAU - Liu, You-Shuo
AU  - Liu YS
AUID- ORCID: 0000-0001-9835-4074
AD  - Department of Geriatrics, 619959The Second Xiangya Hospital of Central South 
      University, Changsha, China.
AD  - Institute of Aging and Age-related Disease Research, Central South University, 
      Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (BHLHE40 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Cross-Sectional Studies
MH  - Carotid Intima-Media Thickness
MH  - Risk Factors
MH  - *Atherosclerosis/diagnostic imaging/epidemiology
MH  - Homeodomain Proteins
MH  - Basic Helix-Loop-Helix Transcription Factors
PMC - PMC10064473
OTO - NOTNLM
OT  - Bhlhe40
OT  - carotid intima-media thickness
OT  - subclinical atherosclerosis
OT  - type 2 diabetes mellitus
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/31 06:41
PMCR- 2023/03/29
CRDT- 2023/03/29 18:32
PHST- 2023/03/31 06:41 [medline]
PHST- 2023/03/29 18:32 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - 10.1177_14791641231169246 [pii]
AID - 10.1177/14791641231169246 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2023 Mar-Apr;20(2):14791641231169246. doi: 
      10.1177/14791641231169246.