PMID- 36990800
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20240331
IS  - 1559-4106 (Electronic)
IS  - 1934-8630 (Print)
IS  - 1559-4106 (Linking)
VI  - 18
IP  - 2
DP  - 2023 Mar 29
TI  - Back to the basics of time-of-flight secondary ion mass spectrometry of 
      bio-related samples. I. Instrumentation and data collection.
PG  - 021201
LID - 10.1116/6.0002477 [doi]
LID - 021201
AB  - Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used widely 
      throughout industrial and academic research due to the high information content 
      of the chemically specific data it produces. Modern ToF-SIMS instruments can 
      generate high mass resolution data that can be displayed as spectra and images 
      (2D and 3D). This enables determining the distribution of molecules across and 
      into a surface and provides access to information not obtainable from other 
      methods. With this detailed chemical information comes a steep learning curve in 
      how to properly acquire and interpret the data. This Tutorial is aimed at helping 
      ToF-SIMS users to plan for and collect ToF-SIMS data. The second Tutorial in this 
      series will cover how to process, display, and interpret ToF-SIMS data.
FAU - Graham, Daniel J
AU  - Graham DJ
AUID- ORCID: 0000-0003-4538-7475
AD  - Department of Bioengineering, NESAC/BIO, University of Washington, Seattle, 
      Washington 98195.
FAU - Gamble, Lara J
AU  - Gamble LJ
AUID- ORCID: 0000-0002-5081-3769
AD  - Department of Bioengineering, NESAC/BIO, University of Washington, Seattle, 
      Washington 98195.
LA  - eng
GR  - P41 EB002027/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20230329
PL  - United States
TA  - Biointerphases
JT  - Biointerphases
JID - 101275679
SB  - IM
MH  - *Spectrometry, Mass, Secondary Ion/methods
MH  - Data Collection
PMC - PMC10063322
COIS- The authors have no conflicts to disclose.
EDAT- 2023/03/30 06:00
MHDA- 2023/03/31 06:42
PMCR- 2024/03/29
CRDT- 2023/03/29 22:02
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/03/29 22:02 [entrez]
PHST- 2023/03/30 06:00 [pubmed]
PHST- 2024/03/29 00:00 [pmc-release]
AID - 6.0002477 [pii]
AID - 10.1116/6.0002477 [doi]
PST - epublish
SO  - Biointerphases. 2023 Mar 29;18(2):021201. doi: 10.1116/6.0002477.