PMID- 36992089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230401
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 11
IP  - 3
DP  - 2023 Feb 22
TI  - Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We 
      Consider Reducing the Dose for Females?
LID - 10.3390/vaccines11030505 [doi]
LID - 505
AB  - An important issue that is often neglected is the difference between male and 
      female genders in response to medical treatments. In the context of COVID-19 
      vaccine administration, despite identical protocol strategies, it has been 
      observed that females often suffer more adverse consequences than males. Here, we 
      analyzed the adverse events (AEs) of the Comirnaty vaccine in a population of 
      2385 healthcare workers as a function of age, sex, COVID-19 history and BMI. 
      Using logistic regression analysis, we showed that these variables may contribute 
      to the development of AEs, particularly in young subjects, females and 
      individuals with a BMI below 25 kg/m(2). Moreover, partial dependence plots 
      indicate a 50% probability of developing a mild AE for a long period of time (>/=7 
      days) or a severe AE of any duration in women below 40 years old and with a BMI < 
      20 kg/m(2). As this effect is more evident after the second dose of the vaccine, 
      we propose to reduce the amount of vaccine for any additional booster dose in 
      relation to age, sex and BMI. This strategy might reduce adverse events without 
      affecting vaccine efficacy.
FAU - Azzolini, Elena
AU  - Azzolini E
AD  - IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072 Pieve Emanuele, MI, Italy.
FAU - Mollura, Maximiliano
AU  - Mollura M
AUID- ORCID: 0000-0002-2248-8145
AD  - Politecnico di Milano, Department of Electronic, Information and Bioengineering, 
      Piazza Leonardo da Vinci 32, 20133 Milano, MI, Italy.
FAU - Pozzi, Chiara
AU  - Pozzi C
AUID- ORCID: 0000-0003-2153-6130
AD  - IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
FAU - Ubaldi, Leonardo
AU  - Ubaldi L
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072 Pieve Emanuele, MI, Italy.
FAU - Mantovani, Alberto
AU  - Mantovani A
AD  - IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072 Pieve Emanuele, MI, Italy.
AD  - The William Harvey Research Institute, Queen Mary University of London, London 
      EC1M 6BQ, UK.
FAU - Selmi, Carlo
AU  - Selmi C
AUID- ORCID: 0000-0002-0323-0376
AD  - IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072 Pieve Emanuele, MI, Italy.
FAU - Barbieri, Riccardo
AU  - Barbieri R
AUID- ORCID: 0000-0001-9381-3833
AD  - Politecnico di Milano, Department of Electronic, Information and Bioengineering, 
      Piazza Leonardo da Vinci 32, 20133 Milano, MI, Italy.
FAU - Rescigno, Maria
AU  - Rescigno M
AUID- ORCID: 0000-0002-6464-509X
AD  - IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072 Pieve Emanuele, MI, Italy.
LA  - eng
GR  - Ricerca Corrente/Ministero della Salute/
PT  - Journal Article
DEP - 20230222
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC10055873
OTO - NOTNLM
OT  - COVID-19
OT  - adverse events
OT  - vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/31 06:00
MHDA- 2023/03/31 06:01
PMCR- 2023/02/22
CRDT- 2023/03/30 01:04
PHST- 2023/01/18 00:00 [received]
PHST- 2023/02/17 00:00 [revised]
PHST- 2023/02/20 00:00 [accepted]
PHST- 2023/03/31 06:01 [medline]
PHST- 2023/03/30 01:04 [entrez]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/02/22 00:00 [pmc-release]
AID - vaccines11030505 [pii]
AID - vaccines-11-00505 [pii]
AID - 10.3390/vaccines11030505 [doi]
PST - epublish
SO  - Vaccines (Basel). 2023 Feb 22;11(3):505. doi: 10.3390/vaccines11030505.