PMID- 3699313
OWN - NLM
STAT- MEDLINE
DCOM- 19860530
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 6
IP  - 2
DP  - 1986 Feb
TI  - Evaluation of the reproductive toxicology of 2,4,6-trichlorophenol in male and 
      female rats.
PG  - 233-9
AB  - The toxicity of chlorinated organic compounds which may be generated as a 
      by-product of drinking water chlorination has been an issue of increasing 
      concern. Relatively few data are available concerning their reproductive 
      toxicity. The present study was designed to evaluate the reproductive effects of 
      one of these compounds, 2,4,6-trichlorophenol (TCP), in male and female rats. 
      Adult males were treated with either 0, 100, 500, or 1000 mg/kg of TCP (po) for 
      10 weeks, at which time semen evaluations were conducted on ejaculates recovered 
      from the genital tract of receptive females. Fertility was assessed in the 0- and 
      1000-mg/kg groups. Females were treated with identical doses for 2 weeks prior to 
      pregnancy then throughout gestation. Dams were allowed to litter and pup 
      development was monitored until Day 42 postpartum. TCP had no effect on any sperm 
      parameter or male fertility. Treatment of females with 1000 mg/kg of TCP produced 
      gross maternal toxicity as reflected in increased lethality and decreased weight 
      gains in the dams. However, no treatment-related differences were seen in litter 
      sizes or pup survival. Male and female birth weights were significantly depressed 
      in the 500- and 1000-mg/kg groups; these differences disappeared by Day 4 
      postpartum, suggesting that they were a reflection of maternal toxicity. To this 
      extent, the reproductive processes of male and female rats do not appear to be a 
      primary target for the effects of TCP.
FAU - Blackburn, K
AU  - Blackburn K
FAU - Zenick, H
AU  - Zenick H
FAU - Hope, E
AU  - Hope E
FAU - Manson, J M
AU  - Manson JM
FAU - George, E L
AU  - George EL
FAU - Smith, M K
AU  - Smith MK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Chlorophenols)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
SB  - IM
MH  - Animals
MH  - Birth Weight/drug effects
MH  - Body Weight/drug effects
MH  - Chlorophenols/metabolism/*toxicity
MH  - Copulation/drug effects
MH  - Female
MH  - Fertility/drug effects
MH  - Fetus/drug effects
MH  - Kinetics
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Reproduction/*drug effects
MH  - Semen/drug effects
MH  - Sexual Behavior, Animal/drug effects
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1986/02/01 00:00
MHDA- 1986/02/01 00:01
CRDT- 1986/02/01 00:00
PHST- 1986/02/01 00:00 [pubmed]
PHST- 1986/02/01 00:01 [medline]
PHST- 1986/02/01 00:00 [entrez]
AID - 10.1016/0272-0590(86)90236-8 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1986 Feb;6(2):233-9. doi: 10.1016/0272-0590(86)90236-8.