PMID- 36993806
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230331
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - The association between retinal microvasculature derived from optical coherence 
      tomography angiography and systemic factors in type 2 diabetics.
PG  - 1107064
LID - 10.3389/fmed.2023.1107064 [doi]
LID - 1107064
AB  - AIMS: To investigate the correlation between the retinal microvasculature using 
      optical coherence tomography angiography (OCTA) and systemic factors in type 2 
      diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study obtained 
      OCTA data from patients with T2DM administered at hospital and referred to 
      ophthalmic services. Patient data about demographics, comorbid conditions, and 
      blood biomarkers were extracted from electronic medical records. Data from OCTA 
      scans obtained by CIRRUS HD-OCT Model 5,000 were obtained. Vessel density (VD) 
      and perfusion density (PD) within the superficial capillary plexus, and foveal 
      avascular zone (FAZ) area were automatically segmented. These parameters were 
      tested for their correlations with systemic factors by univariate and 
      multivariable linear regression analyses. RESULTS: A total of 144 T2DM patients 
      (236 eyes) were available for analysis, with mean age of 53.6 (SD = 10.34) and 
      56.9% were male. Chronic kidney disease, cardiovascular disease, increased serum 
      creatinine (Scr), red blood cell count (RBC), platelets (PLT), apolipoprotein B 
      (APOB), and decreased urine albumin to creatinine ratio (UACR) were significantly 
      associated with lower VD and PD (all p < 0.013). UACR and triglyceride (TRIG) 
      were significantly correlated with FAZ area (all p < 0.017). In multivariate 
      analyses, PLT, eGFR, and APOB were independent risk factors for retinal 
      rarefaction, and UACR was a significant predictor of FAZ area. CONCLUSION: We 
      found several systemic risk factors, such as PLT, renal function and lipid 
      profiles were associated with PD, VD, and FAZ area among Chinese T2DM patients.
CI  - Copyright (c) 2023 Li, Wu, Chen, Xu, Wang, Wang, Bulloch, Borchert and Fan.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
AD  - Shantou University Medical College, Shantou, China.
FAU - Wu, Kunfang
AU  - Wu K
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
FAU - Chen, Zilin
AU  - Chen Z
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
FAU - Xu, Guihua
AU  - Xu G
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
FAU - Wang, Dingding
AU  - Wang D
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
FAU - Wang, Juanjuan
AU  - Wang J
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
FAU - Bulloch, Gabriella
AU  - Bulloch G
AD  - Centre for Eye Research Australia, Melbourne, VIC, Australia.
AD  - The University of Melbourne, Melbourne, VIC, Australia.
FAU - Borchert, Grace
AU  - Borchert G
AD  - Centre for Eye Research Australia, Melbourne, VIC, Australia.
AD  - The University of Melbourne, Melbourne, VIC, Australia.
FAU - Fan, Huiya
AU  - Fan H
AD  - Department of Ophthalmology, Huizhou Central People's Hospital, Huizhou, China.
LA  - eng
PT  - Journal Article
DEP - 20230313
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10040575
OTO - NOTNLM
OT  - OCTA
OT  - T2DM
OT  - correlation
OT  - retinal microvasculature
OT  - systemic factors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/31 06:00
MHDA- 2023/03/31 06:01
PMCR- 2023/03/13
CRDT- 2023/03/30 02:56
PHST- 2022/11/24 00:00 [received]
PHST- 2023/02/22 00:00 [accepted]
PHST- 2023/03/31 06:01 [medline]
PHST- 2023/03/30 02:56 [entrez]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/13 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1107064 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Mar 13;10:1107064. doi: 10.3389/fmed.2023.1107064. 
      eCollection 2023.