PMID- 36994848
OWN - NLM
STAT- MEDLINE
DCOM- 20230503
LR  - 20230503
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 143
IP  - 4
DP  - 2023 Apr
TI  - Predictive value of pathological carcinoma size in patients with T2 glottic 
      laryngeal squamous cell carcinoma.
PG  - 317-321
LID - 10.1080/00016489.2023.2188083 [doi]
AB  - BACKGROUND: T2N0M0 glottic laryngeal squamous cell carcinoma (LSCC) is a common 
      type of laryngeal cancer. OBJECTIVES: The objective of this research was to 
      assess the predictive value of tumor size for the rates of overall survival (OS) 
      and disease-free survival (DFS) as determined by postoperative pathological 
      examination in patients with T2 LSCC. METHODS: A retrospective study was 
      conducted on 535 successive patients with T2 glottic LSCC who underwent operation 
      from 2005 to 2010. The effect of tumor size on OS and DFS results was evaluated 
      by the affected area. RESULTS: Of the cohort, 528 (98.7%) were male, and 7 (1.3%) 
      were female, with an average age of 60.1 +/- 9.4 years. The 10-year DFS and OS 
      rates were 72.1% and 76.3%, respectively. The tumor diameter and area cut-off 
      values that best discriminated OS and DFS rates were 1.35 cm and 1 cm(2), 
      respectively. Patients with glottis carcinoma with a longer tumor diameter and 
      larger tumor area had inferior OS and DFS rates. Tumor diameter and tumor area 
      were independent predictive factors for the rates of OS and DFS in patients with 
      T2 glottic LSCC. CONCLUSION AND SIGNIFICANCE: This research showed that patients 
      with T2 glottic LSCC with a carcinoma diameter >1.35 cm or a tumor area >1 cm(2) 
      have worse survival outcomes. These factors independently predict survival 
      outcomes in patients.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Zhu, Xiaoke
AU  - Zhu X
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Xu, Chengzhi
AU  - Xu C
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230330
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - Retrospective Studies
MH  - *Carcinoma, Squamous Cell
MH  - Glottis/pathology
MH  - *Laryngeal Neoplasms/surgery
MH  - *Head and Neck Neoplasms/pathology
MH  - Prognosis
MH  - Neoplasm Staging
OTO - NOTNLM
OT  - T2 glottic carcinoma
OT  - Tumor size
OT  - prognosis
OT  - surgery
OT  - survival
EDAT- 2023/03/31 06:00
MHDA- 2023/05/03 06:42
CRDT- 2023/03/30 06:33
PHST- 2023/05/03 06:42 [medline]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/30 06:33 [entrez]
AID - 10.1080/00016489.2023.2188083 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2023 Apr;143(4):317-321. doi: 10.1080/00016489.2023.2188083. 
      Epub 2023 Mar 30.