PMID- 36995329
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230921
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 118
IP  - 7
DP  - 2023 Jul 1
TI  - Clinical Presentation of Alpha-Gal Syndrome in Pediatric Gastroenterology and 
      Response to Mammalian Dietary Elimination.
PG  - 1293-1296
LID - 10.14309/ajg.0000000000002268 [doi]
AB  - INTRODUCTION: Alpha-gal syndrome is an immunoglobulin E (IgE)-mediated delayed 
      hypersensitivity reaction to nonprimate mammalian products, which has a newly 
      established gastrointestinal (GI) phenotype in adults. We assessed the GI 
      presentation and treatment response in children. METHODS: This is a retrospective 
      study of patients presenting in a pediatric gastroenterology clinic tested for 
      alpha-gal IgE. RESULTS: Forty of 199 patients (20%) tested had a positive 
      alpha-gal-specific IgE, with 77.5% reporting GI symptoms in isolation. Of the 30 
      that attempted dietary elimination, 8 (27%) experienced full resolution of 
      symptoms. DISCUSSION: Alpha-gal syndrome can present with isolated GI symptoms in 
      children.
CI  - Copyright (c) 2023 by The American College of Gastroenterology.
FAU - Busing, Jordan D
AU  - Busing JD
AUID- ORCID: 0000-0002-1624-315
AD  - Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University 
      Medical Center, Nashville, Tennessee, USA.
FAU - Stone, Cosby A Jr
AU  - Stone CA Jr
AD  - Division of Allergy, Pulmonary, and Critical Care Medicine, Department of 
      Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
FAU - Nicholson, Maribeth R
AU  - Nicholson MR
AD  - Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University 
      Medical Center, Nashville, Tennessee, USA.
LA  - eng
GR  - K23 AI156132/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230328
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 37341-29-0 (Immunoglobulin E)
RN  - red meat allergy
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Gastroenterology
MH  - Retrospective Studies
MH  - *Food Hypersensitivity/diagnosis
MH  - Immunoglobulin E
MH  - Mammals
PMC - PMC10511000
MID - NIHMS1929771
COIS- Potential competing interests: The authors declare no conflicts of interest.
EDAT- 2023/03/31 06:00
MHDA- 2023/06/29 06:43
PMCR- 2024/07/01
CRDT- 2023/03/30 10:53
PHST- 2023/01/24 00:00 [received]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2024/07/01 00:00 [pmc-release]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/30 10:53 [entrez]
AID - 00000434-202307000-00032 [pii]
AID - 10.14309/ajg.0000000000002268 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2023 Jul 1;118(7):1293-1296. doi: 
      10.14309/ajg.0000000000002268. Epub 2023 Mar 28.