PMID- 36995567 OWN - NLM STAT- MEDLINE DCOM- 20230405 LR - 20230405 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 28 IP - 1 DP - 2023 Mar 30 TI - Prefrontal cortex activation by binge-eating status in individuals with obesity while attempting to reappraise responses to food using functional near infrared spectroscopy. PG - 34 LID - 10.1007/s40519-023-01558-z [doi] LID - 34 AB - PURPOSE: Difficulty reappraising drives to consume palatable foods may promote poorer inhibition and binge eating (BE) in adults with obesity, but neural underpinnings of food-related reappraisal are underexamined. METHODS: To examine neural correlates of food-related reappraisal, adults with obesity with and without BE wore a portable neuroimaging tool, functional near-infrared spectroscopy (fNIRS). fNIRS measured activity in the prefrontal cortex while participants watched videos of food and attempt to "resist" the food stimuli (i.e., "consider the negative consequences of eating the food"). RESULTS: Participants (N = 32, 62.5% female; BMI 38.6 [Formula: see text] 7.1; 43.5 [Formula: see text] 13.4 y) had a BMI > 30 kg/m(2). Eighteen adults (67.0% female; BMI 38.2 [Formula: see text] 7.6) reported BE (>/= 12 BE-episodes in preceding 3 months). The control group comprised 14 adults who denied BE (64.0% female; BMI 39.2 [Formula: see text] 6.6). Among the entire sample, mixed models showed significant, small hyperactivation during crave and resist compared to watch (relax) condition bilaterally in the medial superior frontal gyrus, dorsolateral areas, and middle frontal gyrus (optodes 5, 7, 9, 10, 11, and 12) in the total sample. No statistically significant differences in neural activation were observed between the BE and control group. Moreover, there were no significant group by condition interactions on neural activation. CONCLUSION: Among adults with obesity, BE status was not linked to differential activation in inhibitory prefrontal cortex areas during a food-related reappraisal task. Future research is needed with larger samples, adults without obesity, and inhibition paradigms with both behavioral and cognitive components. LEVEL OF EVIDENCE: Level III: Evidence obtained from well-designed cohort or case-control analytic studies. TRIAL REGISTRATION: # NCT03113669, date April 13, 2017. CI - (c) 2023. The Author(s). FAU - Parker, Megan N AU - Parker MN AUID- ORCID: 0000-0003-2511-199X AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. AD - The WELL Center, Drexel University, Philadelphia, PA, USA. AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA. AD - Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA. FAU - Burton Murray, Helen AU - Burton Murray H AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. hbmurray@mgh.harvard.edu. AD - The WELL Center, Drexel University, Philadelphia, PA, USA. hbmurray@mgh.harvard.edu. AD - Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. hbmurray@mgh.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. hbmurray@mgh.harvard.edu. FAU - Piers, Amani D AU - Piers AD AUID- ORCID: 0000-0002-8718-9517 AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. FAU - Muratore, Alexandra AU - Muratore A AUID- ORCID: 0000-0002-2546-1490 AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. FAU - Lowe, Michael R AU - Lowe MR AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. FAU - Manasse, Stephanie M AU - Manasse SM AUID- ORCID: 0000-0002-4666-588X AD - The WELL Center, Drexel University, Philadelphia, PA, USA. FAU - Ayaz, Hasan AU - Ayaz H AUID- ORCID: 0000-0001-5514-2741 AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. AD - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA. AD - Drexel Solutions Institute, Drexel University, Philadelphia, PA, USA. AD - Department of Family and Community Health, University of Pennsylvania, Philadelphia, PA, USA. AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Juarascio, Adrienne S AU - Juarascio AS AUID- ORCID: 0000-0001-6377-4212 AD - Department of Psychology, Drexel University, Philadelphia, PA, USA. AD - The WELL Center, Drexel University, Philadelphia, PA, USA. LA - eng SI - ClinicalTrials.gov/NCT03113669 GR - K23 MH105680/MH/NIMH NIH HHS/United States GR - K23DK124514/DK/NIDDK NIH HHS/United States GR - Student Research Grant/Academy for Eating Disorders/ PT - Clinical Trial PT - Journal Article DEP - 20230330 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - *Binge-Eating Disorder MH - *Bulimia MH - Magnetic Resonance Imaging/methods MH - Obesity MH - Prefrontal Cortex/diagnostic imaging MH - Spectroscopy, Near-Infrared PMC - PMC10063505 OTO - NOTNLM OT - Binge eating OT - Inhibition OT - Inhibitory control OT - Neuroimaging OT - Obesity OT - Reappraisal COIS- fNIR Devices LLC. manufactures the optical brain-imaging instrument and licensed IP and know-how from Drexel University. HA was involved in the technology development and thus offered a minor share in the new startup firm fNIR Devices, LLC. HBM, MNP, SMM, AP, AM, MRL, and ASJ have no personal or financial conflicts of interest to declare. EDAT- 2023/03/31 06:00 MHDA- 2023/04/03 06:42 PMCR- 2023/03/30 CRDT- 2023/03/30 11:21 PHST- 2022/06/11 00:00 [received] PHST- 2023/03/03 00:00 [accepted] PHST- 2023/04/03 06:42 [medline] PHST- 2023/03/30 11:21 [entrez] PHST- 2023/03/31 06:00 [pubmed] PHST- 2023/03/30 00:00 [pmc-release] AID - 10.1007/s40519-023-01558-z [pii] AID - 1558 [pii] AID - 10.1007/s40519-023-01558-z [doi] PST - epublish SO - Eat Weight Disord. 2023 Mar 30;28(1):34. doi: 10.1007/s40519-023-01558-z.