PMID- 36996769
OWN - NLM
STAT- MEDLINE
DCOM- 20230706
LR  - 20230914
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 184
IP  - 7
DP  - 2023
TI  - Association between Polyunsaturated Fatty Acid Intake and Eczema in Children and 
      Adolescents.
PG  - 681-691
LID - 10.1159/000529435 [doi]
AB  - INTRODUCTION: Eczema is a common allergic skin condition among children and 
      adolescents, and polyunsaturated fatty acids (PUFAs) are a kind of fatty acid 
      which were reported to be associated with reduced risk of eczema. Previous 
      studies explored different types of PUFAs with various age groups of children and 
      adolescents, and the influence of confounding factors such as medicine use was 
      not considered. In the present study, we aimed to identify the associations 
      between PUFAs and the risk of eczema in children and adolescents. These findings 
      of our study might help better understand the associations between PUFAs and 
      eczema. METHODS: This cross-sectional study collected the data of 2,560 children 
      and adolescents aged 6-19 years from National Health and Nutrition Examination 
      Surveys (NHANES) between 2005 and 2006. Total PUFA, omega-3 (n-3), including 
      octadecatrienoic acid/18:3, octadecatrienoic acid/18:4, eicosapentaenoic 
      acid/20:5, docosapentaenoic acid/22:5, and docosahexaenoic acid/22:6, omega-6 
      (n-6), including octadecatrienoic acid/18:2 and eicosatetraenoic acid/20:4, total 
      n-3 intake, total n-6 intake, and n-3/n-6 were main variables in this study. 
      Univariate logistic regression was applied for identifying potential confounders 
      for eczema. Univariate and multivariate logistic regression analysis were 
      conducted to explore the associations between PUFAs and eczema. Subgroup analysis 
      was performed on subjects with different ages, and patients complicated with 
      other allergic diseases, allergy, and medicine use or not. RESULTS: In total, 
      there were 252 (9.8%) subjects who had eczema. After adjusting for confounding 
      factors including age, race, poverty to income ratio (PIR), medicine use, hay 
      fever, sinus infection, body mass index (BMI), serum total immunoglobulin E (IgE) 
      antibody, and IgE, we observed that eicosatetraenoic acid/20:4 (OR = 0.17, 95% 
      CI: 0.04-0.68) and total n-3 (OR = 0.88, 95% CI: 0.77-0.99) were linked with 
      decreased risk of eczema in children and adolescents. Eicosatetraenoic acid/20:4 
      was correlated with decreased risk of eczema in participants without hay fever 
      (OR = 0.82, 95% CI: 0.70-0.97) and medicine use (OR = 0.80, 95% CI: 0.68-0.94) or 
      with allergy (OR = 0.75, 95% CI: 0.59-0.94). Total n-3 intake was associated with 
      a reduced risk of eczema with the adjusted OR of 0.84, 95% CI: 0.72-0.98) in 
      participants without hay fever. In those without sinus infection, 
      octadecatrienoic acid/18:4 was linked with decreased risk of eczema (OR = 0.83, 
      95% CI: 0.69-0.99). CONCLUSION: N-3 and eicosatetraenoic acid/20:4 might be 
      associated with the risk of eczema in children and adolescents.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, China.
FAU - Li, Ping
AU  - Li P
AD  - Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, China.
FAU - Fu, Peijun
AU  - Fu P
AD  - Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230330
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Fatty Acids, Omega-3)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Arachidonic Acids)
SB  - IM
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - *Rhinitis, Allergic, Seasonal/complications
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - *Eczema/epidemiology/etiology
MH  - *Hypersensitivity
MH  - *Fatty Acids, Omega-3
MH  - Immunoglobulin E
MH  - Arachidonic Acids
OTO - NOTNLM
OT  - Association
OT  - Children and adolescents
OT  - Eczema
OT  - Polyunsaturated fatty acid
EDAT- 2023/03/31 06:00
MHDA- 2023/07/06 06:42
CRDT- 2023/03/30 18:23
PHST- 2022/10/19 00:00 [received]
PHST- 2023/01/13 00:00 [accepted]
PHST- 2023/07/06 06:42 [medline]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/30 18:23 [entrez]
AID - 000529435 [pii]
AID - 10.1159/000529435 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2023;184(7):681-691. doi: 10.1159/000529435. Epub 2023 
      Mar 30.