PMID- 36996966
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 364
DP  - 2023 Jun
TI  - Amphetamines abuse and depression: Focus on TRPC channels.
PG  - 114391
LID - S0014-4886(23)00075-4 [pii]
LID - 10.1016/j.expneurol.2023.114391 [doi]
AB  - Amphetamines, such as amphetamine (AMPH), methamphetamine (METH) and 
      3,4-methylenedioxymethamphetamine (MDMA), are the psychotropic substances widely 
      abused in the world. Amphetamines abuse can damage dopaminergic and serotonin 
      neurons and cause neuroinflammation and neurotoxicity. Neuropsychiatric disorders 
      induced by amphetamines abuse include depression, anxiety, auditory 
      hallucinations, mania, and cognitive disorders, of which depression has a higher 
      incidence. Transient receptor potential (TRP) channels can regulate the inflow 
      and outflow of Ca(2+). In TRP family, transient receptor potential canonical 
      (TRPC) channels are closely associated with the development of some neurological 
      diseases, such as Parkinson's disease and Alzheimer's disease. However, the 
      correlation between TRPC channels and depression and the specific mechanism of 
      TRPC channels in depression still haven't been fully clarified. This review 
      elaborates the pathophysiological mechanisms of depression induced by 
      amphetamines abuse, the functions of TRPC channels in the nervous system, and the 
      possible correlation between TRPC channels and depression induced by amphetamines 
      abuse, which would provide the theoretical basis for the development of the novel 
      and effective therapeutic drugs for amphetamines abuse-induced depression.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Fu, You-Peng
AU  - Fu YP
AD  - Department of Clinical Pharmacology, School of Pharmacy, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Wang, Yun
AU  - Wang Y
AD  - Department of Clinical Pharmacology, School of Pharmacy, China Medical 
      University, Shenyang, Liaoning, China. Electronic address: ywang28@cmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230328
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Transient Receptor Potential Channels)
RN  - 0 (Amphetamines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 0 (Central Nervous System Stimulants)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - *Transient Receptor Potential Channels
MH  - Depression/chemically induced
MH  - Amphetamines/adverse effects
MH  - *Methamphetamine
MH  - *Central Nervous System Stimulants/toxicity
MH  - Amphetamine
OTO - NOTNLM
OT  - 3,4-methylenedioxymethamphetamine
OT  - Amphetamine
OT  - Depression
OT  - Methamphetamine
OT  - TRPC
COIS- Declaration of Competing Interest The authors declare that there are no conflicts 
      of interest.
EDAT- 2023/03/31 06:00
MHDA- 2023/05/01 06:42
CRDT- 2023/03/30 19:25
PHST- 2022/12/07 00:00 [received]
PHST- 2023/03/13 00:00 [revised]
PHST- 2023/03/25 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/30 19:25 [entrez]
AID - S0014-4886(23)00075-4 [pii]
AID - 10.1016/j.expneurol.2023.114391 [doi]
PST - ppublish
SO  - Exp Neurol. 2023 Jun;364:114391. doi: 10.1016/j.expneurol.2023.114391. Epub 2023 
      Mar 28.