PMID- 36997952
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230510
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Mar 30
TI  - The effects of a low carbohydrate diet combined with partial meal replacement on 
      obese individuals.
PG  - 18
LID - 10.1186/s12986-023-00740-5 [doi]
LID - 18
AB  - OBJECTIVE: We explored the dietary effects of replacing normal dietary staple 
      foods with supplementary nutritional protein powder, dietary fiber, and fish oil 
      on several metabolic parameters. We examined weight loss, glucose and lipid 
      metabolism, and intestinal flora in obese individuals when compared with 
      individuals on a reduced staple food low carbohydrate diet. METHODS: From 
      inclusion and exclusion criteria, 99 participants (28 kg/m(2) </= body mass index 
      (BMI) </= 35 kg/m(2)) were recruited and randomly assigned to control and 
      intervention 1 and 2 groups. Physical examinations and biochemical indices were 
      performed/gathered before the intervention and at 4 and 13 weeks post 
      intervention. After 13 weeks, feces was collected and 16s rDNA sequenced. 
      RESULTS: After 13 weeks, when compared with controls, body weight, BMI, waist 
      circumference, hip circumference, systolic blood pressure, and diastolic blood 
      pressure values in intervention group 1 were significantly reduced. In 
      intervention group 2, body weight, BMI, waist circumference, and hip 
      circumference were significantly reduced. Triglyceride (TG) levels in both 
      intervention groups were significantly reduced. Fasting blood glucose, 
      glycosylated hemoglobin, glycosylated albumin, total cholesterol, and 
      apolipoprotein B levels in intervention group 1 were decreased, while high 
      density lipoprotein cholesterol (HDL-c) decreased slightly. Glycosylated albumin, 
      TG, and total cholesterol levels in intervention group 2 decreased, while HDL-c 
      decreased slightly, High sensitive C-reactive protein, MPO, Ox-LDL, LEP, 
      TGF-beta(1), IL-6, GPLD1, pro NT, GPC-4, and LPS levels in both intervention groups 
      were lower when compared with controls. Adiponectin (ADPN) levels in intervention 
      groups were higher when compared with controls. Tumor necrosis factor-alpha (TNF-alpha) 
      levels in intervention group 1 were lower when compared with controls. There is 
      no obvious difference in alpha diversity and beta diversity between intestinal flora of 
      3 groups. Among the first 10 species of Phylum, only the control group and the 
      intervention group 2 had significantly higher Patescibacteria than the 
      intervention group 1. Among the first 10 species of Genus, only the number of 
      Agathobacter in intervention group 2 was significantly higher than that in 
      control group and intervention group 1. CONCLUSIONS: We showed that an LCD, where 
      nutritional protein powder replaced some staple foods and dietary fiber and fish 
      oil were simultaneously supplemented, significantly reduced weight and improved 
      carbohydrate and lipid metabolism in obese individuals when compared with an LCD 
      which reduced staple food intake.
CI  - (c) 2023. The Author(s).
FAU - Zhong, Yulian
AU  - Zhong Y
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Chen, Ximin
AU  - Chen X
AD  - Beijing Institute of Nutritional Resources, Beijing, 100069, China.
FAU - Huang, Chao
AU  - Huang C
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Chen, Yuexiao
AU  - Chen Y
AD  - Institute of Biotechnology and Health, Beijing Academy of Science and Technology, 
      Beijing, 100089, China.
FAU - Zhao, Fengyi
AU  - Zhao F
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Hao, Runhua
AU  - Hao R
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Wang, Niannian
AU  - Wang N
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Liao, Wang
AU  - Liao W
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Xia, Hui
AU  - Xia H
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Yang, Ligang
AU  - Yang L
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
FAU - Wang, Shaokang
AU  - Wang S
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China. shaokangwang@seu.edu.cn.
FAU - Sun, Guiju
AU  - Sun G
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, Jiangsu, 210009, China.
LA  - eng
GR  - 2016YFD0400604/the13th Five Year National Key R&D Program/
PT  - Journal Article
DEP - 20230330
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
EIN - Nutr Metab (Lond). 2023 May 10;20(1):27. PMID: 37165390
PMC - PMC10064565
OTO - NOTNLM
OT  - Low carbohydrate diet
OT  - Obesity
OT  - Substitute meal
OT  - Weight-loss
COIS- The authors report no conflict of interest.
EDAT- 2023/03/31 06:00
MHDA- 2023/03/31 06:01
PMCR- 2023/03/30
CRDT- 2023/03/30 23:36
PHST- 2022/11/16 00:00 [received]
PHST- 2023/03/20 00:00 [accepted]
PHST- 2023/03/31 06:01 [medline]
PHST- 2023/03/30 23:36 [entrez]
PHST- 2023/03/31 06:00 [pubmed]
PHST- 2023/03/30 00:00 [pmc-release]
AID - 10.1186/s12986-023-00740-5 [pii]
AID - 740 [pii]
AID - 10.1186/s12986-023-00740-5 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2023 Mar 30;20(1):18. doi: 10.1186/s12986-023-00740-5.