PMID- 36998013 OWN - NLM STAT- MEDLINE DCOM- 20230403 LR - 20230403 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 24 IP - 1 DP - 2023 Mar 30 TI - The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease. PG - 98 LID - 10.1186/s12931-023-02405-6 [doi] LID - 98 AB - PURPOSE: Study the impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease (COPD) patients. METHODS: This was a prospective study. Patients with COPD were recruited into the study and followed up for one year. Pittsburgh sleep quality index (PSQI) was collected at baseline. Symptom change was assessed with Minimum clinically important difference (MCID) in COPD Assessment Test (CAT) at 6-month visit, which is an indicator to assess symptom improvement. Exacerbation was recorded during the one-year visit. PSQI score > 5 was defined as poor sleep quality, whereas PSQI score /= 2. RESULTS: A total of 461 patients were enrolled for final analysis. Two hundred twenty-eight (49.4%) patients had poor sleep quality. Overall, 224 (48.6%) patients attained MCID at 6-month visit and the incidence of exacerbation during the one-year visit was 39.3%. Fewer patients with impaired sleep quality achieved MCID than patients with good sleep quality. Good sleepers were significantly more likely to attain MCID (OR: 3.112, p < 0.001) than poor sleepers. Fewer poor sleepers in GOLD A and D groups attained MCID with ICS/LABA, and fewer poor sleepers in the GOLD D group attained MCID with ICS/LABA/LAMA than good sleepers. Poor sleep quality was a greater risk factor of future exacerbation in Cox regression analysis. The ROC curves showed that PSQI score had a predictive capacity for future exacerbation. More patients with poor sleep quality experienced future exacerbation in GOLD B and D group with treatment of ICS/LABA/LAMA compared to good sleepers. CONCLUSIONS: COPD patients with impaired sleep quality were less likely to achieve symptom improvement and were at increased risk of future exacerbation compared to patients with good sleep quality. Besides, sleep disturbance may affect the symptom improvement and future exacerbation of patients with different inhaled medication or in different GOLD groups. CI - (c) 2023. The Author(s). FAU - Lin, Ling AU - Lin L AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Song, Qing AU - Song Q AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Duan, Jiaxi AU - Duan J AD - Geriatrics Department, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Liu, Cong AU - Liu C AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Cheng, Wei AU - Cheng W AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Zhou, Aiyuan AU - Zhou A AD - Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Peng, Yating AU - Peng Y AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Zhou, Zijing AU - Zhou Z AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Zeng, Yuqin AU - Zeng Y AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Chen, Yan AU - Chen Y AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Cai, Shan AU - Cai S AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. FAU - Chen, Ping AU - Chen P AD - Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, China. pingchen0731@csu.edu.cn. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. pingchen0731@csu.edu.cn. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China. pingchen0731@csu.edu.cn. LA - eng GR - 81970044/National Natural Science Foundation of China/ PT - Journal Article DEP - 20230330 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - 0 (Adrenergic beta-2 Receptor Agonists) RN - 0 (Muscarinic Antagonists) RN - 0 (Adrenal Cortex Hormones) SB - IM MH - Humans MH - *Sleep Quality MH - Prospective Studies MH - Disease Progression MH - *Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology/drug therapy MH - Risk Factors MH - Adrenergic beta-2 Receptor Agonists MH - Muscarinic Antagonists MH - Administration, Inhalation MH - Adrenal Cortex Hormones PMC - PMC10064786 OTO - NOTNLM OT - COPD OT - Exacerbation OT - Sleep quality OT - Symptom change COIS- The authors declare that they have no competing interests. EDAT- 2023/03/31 06:00 MHDA- 2023/04/03 06:42 PMCR- 2023/03/30 CRDT- 2023/03/30 23:40 PHST- 2022/06/17 00:00 [received] PHST- 2023/03/20 00:00 [accepted] PHST- 2023/04/03 06:42 [medline] PHST- 2023/03/30 23:40 [entrez] PHST- 2023/03/31 06:00 [pubmed] PHST- 2023/03/30 00:00 [pmc-release] AID - 10.1186/s12931-023-02405-6 [pii] AID - 2405 [pii] AID - 10.1186/s12931-023-02405-6 [doi] PST - epublish SO - Respir Res. 2023 Mar 30;24(1):98. doi: 10.1186/s12931-023-02405-6.