PMID- 36999462
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20240321
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 48
IP  - 2
DP  - 2023 Feb 28
TI  - Correlation between expression of Lin28B and C-myc in patients with laryngeal 
      squamous cell carcinoma and clinicopathological features and prognosis.
PG  - 165-171
LID - 1672-7347(2023)02-0165-07 [pii]
LID - 10.11817/j.issn.1672-7347.2023.220421 [doi]
AB  - OBJECTIVES: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor 
      of head and neck. Screening of target genes for malignant tumor therapy is one of 
      the focuses of cancer research, with proto-oncogene and tumor suppressor gene as 
      the breakthrough. It has become an urgent need to find the target gene related to 
      the treatment and prognosis of LSCC.This study aims to explore the role of Lin28B 
      and C-myc in LSCC by detecting the expressions of these two proteins and analyze 
      the correlation between the expression of Lin28B and C-myc and 
      clinicopathological features and prognosis of LSCC. METHODS: We detected the 
      expression of Lin28B and C-myc proteins in 102 specimens of LSCC and 90 specimens 
      of adjacent tissues by immunochemistry, and analyzed the correlation between 
      Lin28B and C-myc protein expressions in LSCC as well as the correlation between 
      the expressions of the two proteins and the clinicopathological features of LSCC. 
      At the same time, the Kaplan-Meier method was used to analyze the relation 
      between Lin28B and C-myc protein levels with the postoperative survival rate of 
      LSCC patients. RESULTS: The protein levels of Lin28B and C-myc in the LSCC 
      tissnes were significantly higher than those in the adjacent tissues (both 
      P<0.05),and there was a positive correlation between the expression of Lin28B and 
      C-myc in LSCC (r＝0.476, P<0.05). The expression of Lin28B protein was closely 
      related to age, lymph node metastasis, clinical stage, tumor size, and 
      pathological differentiation of LSCC patients (all P<0.05). while the expression 
      of C-myc protein was closely related to lymph node metastasis, clinical stage, 
      tumor size, and pathological differentiation of LSCC patients (all P<0.05). A 
      relevant survival analysis showed that in patients with higher level of Lin28B 
      (P＝0.001) or C-myc protein (P<0.001), the postoperative survival rate was 
      relatively low. CONCLUSIONS: Lin28B and C-myc proteins are highly expressed in 
      LSCC with a positive correlation. Furthermore, they are closely related to lymph 
      node metastasis, clinical stage, tumor size, pathological differentiation and 
      prognosis, suggesting that both Lin28B and C-myc might be involved in the 
      occurrence and development of LSCC.
FAU - Liao, Feifei
AU  - Liao F
AD  - Department of Pathology, Third Xiangya Hospital, Central South University, 
      Changsha 410013. 604615821@qq.com.
FAU - Cao, Yuxin
AU  - Cao Y
AD  - Department of Pathology, Third Xiangya Hospital, Central South University, 
      Changsha 410013.
FAU - Huang, Meixiang
AU  - Huang M
AD  - Department of Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, 
      Central South University, Changsha 410013, China.
FAU - Chu, Ling
AU  - Chu L
AD  - Department of Pathology, Third Xiangya Hospital, Central South University, 
      Changsha 410013. 1799417560@qq.com.
FAU - Wang, Tiansheng
AU  - Wang T
AD  - Department of Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, 
      Central South University, Changsha 410013, China.
LA  - eng
LA  - chi
GR  - 82270003/the National Natural Science Foundation/
GR  - kq2202429/the Natural Science Foundation of Changsha/
PT  - Journal Article
TT  - Lin28B和C-myc蛋白在喉鳞癌中的表达及其与临床病理特征和预后的相关性.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (LIN28B protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Proto-Oncogene Proteins c-myc/metabolism
MH  - *Laryngeal Neoplasms/genetics/diagnosis
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Lymphatic Metastasis
MH  - Prognosis
MH  - *Head and Neck Neoplasms
MH  - Biomarkers, Tumor/metabolism
MH  - RNA-Binding Proteins/genetics
PMC - PMC10930344
OAB - OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor 
      of head and neck. Screening of target genes for malignant tumor therapy is one of 
      the focuses of cancer research, with proto-oncogene and tumor suppressor gene as 
      the breakthrough. It has become an urgent need to find the target gene related to 
      the treatment and prognosis of LSCC.This study aims to explore the role of Lin28B 
      and C-myc in LSCC by detecting the expressions of these two proteins and analyze 
      the correlation between the expression of Lin28B and C-myc and 
      clinicopathological features and prognosis of LSCC. METHODS: We detected the 
      expression of Lin28B and C-myc proteins in 102 specimens of LSCC and 90 specimens 
      of adjacent tissues by immunochemistry, and analyzed the correlation between 
      Lin28B and C-myc protein expressions in LSCC as well as the correlation between 
      the expressions of the two proteins and the clinicopathological features of LSCC. 
      At the same time, the Kaplan-Meier method was used to analyze the relation 
      between Lin28B and C-myc protein levels with the postoperative survival rate of 
      LSCC patients. RESULTS: The protein levels of Lin28B and C-myc in the LSCC 
      tissnes were significantly higher than those in the adjacent tissues (both 
      P<0.05),and there was a positive correlation between the expression of Lin28B and 
      C-myc in LSCC (r＝0.476, P<0.05). The expression of Lin28B protein was closely 
      related to age, lymph node metastasis, clinical stage, tumor size, and 
      pathological differentiation of LSCC patients (all P<0.05). while the expression 
      of C-myc protein was closely related to lymph node metastasis, clinical stage, 
      tumor size, and pathological differentiation of LSCC patients (all P<0.05). A 
      relevant survival analysis showed that in patients with higher level of Lin28B 
      (P＝0.001) or C-myc protein (P<0.001), the postoperative survival rate was 
      relatively low. CONCLUSION: Lin28B and C-myc proteins are highly expressed in 
      LSCC with a positive correlation. Furthermore, they are closely related to lymph 
      node metastasis, clinical stage, tumor size, pathological differentiation and 
      prognosis, suggesting that both Lin28B and C-myc might be involved in the 
      occurrence and development of LSCC.
OABL- eng
OTO - NOTNLM
OT  - C-myc
OT  - Lin28B
OT  - clinicopathological features
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
COIS- 作者声称无任何利益冲突。
EDAT- 2023/04/01 06:00
MHDA- 2023/04/03 06:42
PMCR- 2023/02/28
CRDT- 2023/03/31 05:13
PHST- 2023/04/03 06:42 [medline]
PHST- 2023/03/31 05:13 [entrez]
PHST- 2023/04/01 06:00 [pubmed]
PHST- 2023/02/28 00:00 [pmc-release]
AID - 1672-7347(2023)02-0165-07 [pii]
AID - 10.11817/j.issn.1672-7347.2023.220421 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Feb 28;48(2):165-171. doi: 
      10.11817/j.issn.1672-7347.2023.220421.