PMID- 37001388
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230512
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 281
DP  - 2023 Jun
TI  - Comparison of the cross-protection of PPRSV sublineage 8.7 MLV vaccines against 
      the recombinant NADC30-like strain.
PG  - 109724
LID - S0378-1135(23)00076-7 [pii]
LID - 10.1016/j.vetmic.2023.109724 [doi]
AB  - The emergence of recombinant porcine reproductive and respiratory syndrome virus 
      (PRRSV) has caused a substantial threat to the swine industry in recent years. 
      However, the protective efficacy of different sublineage 8.7 PRRSV modified-live 
      virus (MLV) vaccines against emerging strains were still obscure. In this study, 
      a broad epidemiological investigation of PRRSV showed the prevalence of 
      NADC30-like strain increased in Shandong Province, China from 2018 to 2020. 
      Through piglet trial for vaccination and challenge with recombinant NADC30-like 
      SDlz1601 strain, CH-1R MLV vaccine showed better protective effect than JXA1-R 
      and TJM-F92 MLV vaccines in terms of clinical score and pathological observation. 
      Moreover, all three MLV vaccines could reduce virus loads in the serum of 
      piglets. This study provides valuable insights into the prevalence of the 
      NADC30-like strain and the protective effect of PRRS MLV vaccines against 
      recombinant NADC30-like strains, which could help to improve the prevention and 
      control of PRRSV infections.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Li, Jianda
AU  - Li J
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Meng, Kai
AU  - Meng K
AD  - Shandong Key Laboratory of Poultry Diseases Diagnosis and Immunology, Poultry 
      Breeding Engineering Technology Center of Shandong Province, Institute of Poultry 
      Science, Shandong Academy of Agricultural Sciences, Jinan 250023, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China; College of Animal Science and Technology, Shandong 
      Agricultural University, Tai'an 271018, China.
FAU - Wang, Zhao
AU  - Wang Z
AD  - School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First 
      Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.
FAU - Peng, Jun
AU  - Peng J
AD  - College of Animal Science and Technology, Shandong Agricultural University, 
      Tai'an 271018, China.
FAU - Ren, Sufang
AU  - Ren S
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Zhang, Yuyu
AU  - Zhang Y
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China; School of Life Sciences, Shandong Normal 
      University, Jinan 250014, China.
FAU - Guo, Lihui
AU  - Guo L
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Liu, Fei
AU  - Liu F
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Lv, Tingting
AU  - Lv T
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China; School of Life Sciences, Shandong Normal 
      University, Jinan 250014, China.
FAU - Jiao, Jian
AU  - Jiao J
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Liu, Yanyan
AU  - Liu Y
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Chen, Zhi
AU  - Chen Z
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Sun, Wenbo
AU  - Sun W
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China.
FAU - Yang, Guiwen
AU  - Yang G
AD  - School of Life Sciences, Shandong Normal University, Jinan 250014, China.
FAU - Yu, Jiang
AU  - Yu J
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China. Electronic address: yujiang_2213@163.com.
FAU - Wu, Jiaqiang
AU  - Wu J
AD  - Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of 
      Animal Science and Veterinary Medicine, Shandong Academy of Agricultural 
      Sciences, Jinan 250100, China; School of Life Sciences, Shandong Normal 
      University, Jinan 250014, China. Electronic address: wujiaqiang2000@sina.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20230313
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Cross Protection
MH  - Phylogeny
MH  - *Porcine Reproductive and Respiratory Syndrome/prevention & control
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - Swine
MH  - *Swine Diseases/prevention & control
MH  - Vaccines, Attenuated
MH  - *Viral Vaccines
OTO - NOTNLM
OT  - Cross-protection
OT  - Epidemiology
OT  - Modified-live virus vaccine
OT  - NADC30-like strain
OT  - PRRSV
EDAT- 2023/04/01 06:00
MHDA- 2023/05/08 10:17
CRDT- 2023/03/31 18:08
PHST- 2022/12/03 00:00 [received]
PHST- 2023/03/06 00:00 [revised]
PHST- 2023/03/12 00:00 [accepted]
PHST- 2023/05/08 10:17 [medline]
PHST- 2023/04/01 06:00 [pubmed]
PHST- 2023/03/31 18:08 [entrez]
AID - S0378-1135(23)00076-7 [pii]
AID - 10.1016/j.vetmic.2023.109724 [doi]
PST - ppublish
SO  - Vet Microbiol. 2023 Jun;281:109724. doi: 10.1016/j.vetmic.2023.109724. Epub 2023 
      Mar 13.