PMID- 37002268
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230419
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Mar 31
TI  - Association between nonalcoholic fatty liver disease and peripheral neuropathy in 
      US population, a cross-sectional study.
PG  - 5304
LID - 10.1038/s41598-023-32115-4 [doi]
LID - 5304
AB  - Nonalcoholic fatty liver disease (NAFLD) has become an important risk of type 2 
      diabetes mellitus (T2DM). Peripheral neuropathy (PN) is regarded as one of the 
      main microvascular complications of diabetes. But the association of NAFLD with 
      PN is still unclear. We aimed to investigate the association between NAFLD and PN 
      in US population by conducting a cross-sectional study. We enrolled 3029 
      participants aged 40-85 years from National Health and Nutrition Examination 
      Survey (NHANES) 1999-2004. NAFLD was defined as a US Fatty Liver Index (FLI) 
      score >/= 30, and PN was defined as having one or more insensate areas on either 
      foot. Participants were divided into two groups (with or without PN). We 
      performed multivariate logistic regression models to evaluate the association 
      between NAFLD and PN. Subgroup analyses were used to find out whether the 
      association was stable in different stratified groups. Sensitivity analyses were 
      conducted to assess the robustness of the results. All the analyses were 
      weighted. Among the individuals, 524 (17.3%) had PN and 1250 (41.27%) had NAFLD. 
      In the multivariate logistic regression models, NAFLD was associated with an 
      increased risk of PN (OR 1.44 [1.03 ~ 2.02]) after fully adjusting for 
      covariates. In the subgroup analyses, NAFLD was significantly associated with PN 
      in the age group (40-64 years), compared with those in the age group 
      (65-85 years), (P for interaction: 0.004). The results of association of NAFLD 
      with PN were stable in sensitivity analyses. In this cross-sectional study among 
      US adults aged 40-85 years old, NAFLD was associated with an increased likelihood 
      of prevalent PN.
CI  - (c) 2023. The Author(s).
FAU - Gu, Xi
AU  - Gu X
AD  - Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong 
      University School of Medicine, No. 149 Chongqing South Road, Shanghai, China.
FAU - Tang, Dou
AU  - Tang D
AD  - Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong 
      University School of Medicine, No. 149 Chongqing South Road, Shanghai, China.
FAU - Xuan, Yan
AU  - Xuan Y
AD  - Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong 
      University School of Medicine, No. 149 Chongqing South Road, Shanghai, China.
FAU - Shen, Ying
AU  - Shen Y
AD  - Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong 
      University School of Medicine, No. 149 Chongqing South Road, Shanghai, China. 
      shenying902@163.com.
FAU - Lu, Lei Qun
AU  - Lu LQ
AD  - Department of Endocrinology, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong 
      University School of Medicine, No. 149 Chongqing South Road, Shanghai, China. 
      llqlzy@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230331
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - *Non-alcoholic Fatty Liver Disease/complications/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - *Peripheral Nervous System Diseases/etiology/complications
MH  - Risk Factors
PMC - PMC10066263
COIS- The authors declare no competing interests.
EDAT- 2023/04/01 06:00
MHDA- 2023/04/04 06:42
PMCR- 2023/03/31
CRDT- 2023/03/31 23:18
PHST- 2022/12/31 00:00 [received]
PHST- 2023/03/22 00:00 [accepted]
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/03/31 23:18 [entrez]
PHST- 2023/04/01 06:00 [pubmed]
PHST- 2023/03/31 00:00 [pmc-release]
AID - 10.1038/s41598-023-32115-4 [pii]
AID - 32115 [pii]
AID - 10.1038/s41598-023-32115-4 [doi]
PST - epublish
SO  - Sci Rep. 2023 Mar 31;13(1):5304. doi: 10.1038/s41598-023-32115-4.