PMID- 37002628
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230607
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Feb 20
TI  - Association of Killer Cell Immunoglobulin-like Receptor (KIR) Genes and their HLA 
      Ligands with Susceptibility to Takayasu Arteritis in the Iranian Population.
PG  - 25-33
LID - 10.18502/ijaai.v22i1.12003 [doi]
AB  - Takayasu arteritis (TA) is a chronic inflammatory disorder characterized by 
      vascular damage and fibrosis in the intima that commonly occurs in the aorta. In 
      many damaged sites in TA patients, natural killer (NK) cells have been shown to 
      be hyperactivated and produce inflammatory cytokines and toxic components. Killer 
      cell immunoglobulin-like receptors (KIRs) are found on NK cells and interact with 
      human leukocyte antigen (HLA) class I ligands to activate or suppress NK cells. 
      The present study assessed the possible role of KIR and their HLA ligand genes in 
      susceptibility to TA in Iranian patients. This case-control study included 50 TA 
      patients and 50 healthy subjects. DNA was extracted from whole peripheral blood 
      samples, and polymerase chain reaction with sequence-specific primers (PCR-SSP) 
      was performed to recognize the presence or absence of polymorphism in 17 KIR 
      genes and 5 HLA class I ligands in each participant. Among the KIR and HLA genes, 
      a significant decrease was detected in the frequency of 2DS4 (full allele) in TA 
      patients (38%) compared with healthy controls (82%) (OR=0.13, 95% CI=0.05-0.34). 
      However, none of the KIR and HLA genotypes or the interactions between these 
      genes were associated with susceptibility to TA. The KIR2DS4 gene might be 
      involved in the regulation of activation as well as the production of cytotoxic 
      mediators of NK cells in patients with TA.
FAU - Beigmohammadi, Fereshteh
AU  - Beigmohammadi F
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. fereshtebeig1680@gmail.com.
FAU - Aslani, Saeed
AU  - Aslani S
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. said.aslany@gmail.com.
FAU - Kavosi, Hoda
AU  - Kavosi H
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran 
      AND Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. h-kavosi@sina.tums.ac.ir.
FAU - Javinani, Ali
AU  - Javinani A
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. javinaniali@gmail.com.
FAU - Mostafaei, Shayan
AU  - Mostafaei S
AD  - Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and 
      Society, Karolinska Institutet, Stockholm, Sweden. shayanmostafaee@yahoo.com.
FAU - Pournazari, Mehran
AU  - Pournazari M
AD  - Clinical Research Department Center, Imam Raza Hospital, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran. mehran.pournazari@kums.ac.ir.
FAU - Tasorian, Baharak
AU  - Tasorian B
AD  - Division of Rheumatology, Department of Internal Medicine, Arak University of 
      Medical Sciences, Arak, Iran. bahartasorian2002@yahoo.com.
FAU - Farhadi, Elham
AU  - Farhadi E
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran 
      AND Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. farhadie@tums.ac.ir.
FAU - Hajiabbasi, Asghar
AU  - Hajiabbasi A
AD  - Department of Rheumatology, Guilan Rheumatology Research Center, School of 
      Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 
      mahmoudim@tums.ac.ir.
FAU - Zayeni, Habib
AU  - Zayeni H
AD  - Department of Rheumatology, Guilan Rheumatology Research Center, School of 
      Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 
      zayeni_h@yahoo.com.
FAU - Khabbazi, Alireza
AU  - Khabbazi A
AD  - Connective Tissue Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran. khabbazia@tbzmed.ac.ir.
FAU - Jamshidi, Ahmadreza
AU  - Jamshidi A
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. jamshida@sina.tums.ac.ir.
FAU - Shenavar Masooleh, Irandokht
AU  - Shenavar Masooleh I
AD  - Department of Rheumatology, Guilan Rheumatology Research Center, School of 
      Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 
      shenavar44@yahoo.com.
FAU - Tamartash, Zahra
AU  - Tamartash Z
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. zahra.tamartash73@gmail.com.
FAU - Vojdanian, Mahdi
AU  - Vojdanian M
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. mahmoudim@tums.ac.ir.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran 
      AND Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. mahmoudim@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20230220
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Humans
MH  - Iran/epidemiology
MH  - Ligands
MH  - *Takayasu Arteritis/genetics
MH  - Case-Control Studies
MH  - Receptors, KIR/genetics
MH  - Genotype
MH  - Gene Frequency
OTO - NOTNLM
OT  - Genetic association
OT  - Killer cell immunoglobulin-like receptor
OT  - Natural killer cell
OT  - Takayasu arteritis
EDAT- 2023/04/02 06:00
MHDA- 2023/04/04 06:42
CRDT- 2023/04/01 02:17
PHST- 2021/11/03 00:00 [received]
PHST- 2022/10/24 00:00 [accepted]
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/04/01 02:17 [entrez]
PHST- 2023/04/02 06:00 [pubmed]
AID - 10.18502/ijaai.v22i1.12003 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):25-33. doi: 
      10.18502/ijaai.v22i1.12003.