PMID- 37002758
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230404
IS  - 2408-8757 (Electronic)
IS  - 1022-4742 (Linking)
VI  - 32
IP  - 2
DP  - 2023 Apr
TI  - Role of Vitamin B12 Deficiency and Hyperhomocysteinemia in Diabetic Retinopathy.
PG  - 459-462
AB  - Diabetic retinopathy (DR) is one of the most important causes of preventable 
      visual impairment among patients of working age and leading cause of blindness. 
      Deficiency of vitamin B12 and folate has been associated with increased serum 
      homocysteine (Hcy) levels. This study was done to find out the role of vitamin 
      B12 and Hyperhomocysteine (HHcy) in Diabetic retinopathy. The present study is a 
      hospital-based case-control study conducted during over a period of 12 months 
      from January 2019 to December 2019 study conducted in the Department of 
      Ophthalmology at BIRDEM General Hospital, Dhaka, Bangladesh consisting of 100 
      Type 2 DM patients either with or without retinopathy (DR, n=50 and DNR, n=50, 
      respectively). Subjects with Type 2 DM with and without retinopathy were 
      recruited from patients attending in the department of Ophthalmology at BIRDEM 
      General Hospital, Dhaka and were matched for duration of diabetes. Diabetes 
      subjects on nutritional supplements for the last 6 months and those with a 
      history of nephropathy (based standard renal function tests) and complications 
      other than DR were excluded. Homocysteine (Hcy) levels were inversely related 
      (p<0.05) with Diabetes patients with retinopathy. Vitamin B12 also significant 
      correlated with Diabetes patients with retinopathy. A statistically significant 
      negative linear relationship was found between serum homocysteine and vitamin B12 
      levels (Pearson r = -0.918, p=0.001) Diabetes patients with retinopathy. Vitamin 
      B12 significantly correlated with diabetes retinopathy and homocysteine levels 
      were inversely related with diabetes patients with retinopathy.
FAU - Debnath, P R
AU  - Debnath PR
AD  - Dr Purabi Rani Debnath, Professor and Head, Department of Ophthalmology, BIRDEM 
      General Hospital, Dhaka, Bangladesh.
FAU - Debnath, D K
AU  - Debnath DK
FAU - Haque, A F
AU  - Haque AF
FAU - Mohammuddunnobi, M
AU  - Mohammuddunnobi M
FAU - Bhowmik, N C
AU  - Bhowmik NC
LA  - eng
PT  - Journal Article
PL  - Bangladesh
TA  - Mymensingh Med J
JT  - Mymensingh medical journal : MMJ
JID - 9601799
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/complications
MH  - Case-Control Studies
MH  - *Hyperhomocysteinemia/complications
MH  - Bangladesh/epidemiology
MH  - *Vitamin B 12 Deficiency/complications
MH  - Vitamin B 12
MH  - *Diabetes Mellitus, Type 2
EDAT- 2023/04/02 06:00
MHDA- 2023/04/04 06:42
CRDT- 2023/04/01 04:33
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/04/01 04:33 [entrez]
PHST- 2023/04/02 06:00 [pubmed]
PST - ppublish
SO  - Mymensingh Med J. 2023 Apr;32(2):459-462.