PMID- 37002778
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230720
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 189
IP  - 2
DP  - 2023 Jul 17
TI  - Facial involvement is reflective of patients' global perception of vitiligo 
      extent.
PG  - 188-194
LID - 10.1093/bjd/ljad109 [doi]
AB  - BACKGROUND: The involvement of visible areas in vitiligo has been found to be 
      correlated with increased psychiatric morbidity. Although multiple tools have 
      been developed to assess vitiligo, no cutoff for improvement or worsening of 
      vitiligo from a patient's perspective has been established. OBJECTIVES: To 
      determine the minimal clinically important difference (MCID) of the 
      Self-Assessment Vitiligo Extent Score (SA-VES) in patients with vitiligo and to 
      evaluate, from the patient's perspective, the importance of the change in the 
      involvement of visible areas (face and hands) in patients' overall perception of 
      disease worsening or improving. METHODS: This was a cross-sectional study in the 
      context of the ComPaRe e-cohort. Adult patients with vitiligo were invited to 
      answer online questionnaires. They completed the SA-VES twice, 1 year apart. In 
      addition, patients answered a 5-point Likert anchor question aimed at assessing 
      their perception of the evolution of the extent of their vitiligo. The MCID was 
      calculated using distribution- and anchor-based approaches. Using ordinal 
      logistic regression, the change of vitiliginous lesions on the face or hands was 
      compared to the overall extent of vitiligo (patches on all body areas). RESULTS: 
      In total, 244 patients with vitiligo were included in the analyses; 20 (8%) were 
      found to have an improvement in their vitiligo. The MCID in worsened patients was 
      equal to a 1.3% body surface area [95% confidence interval (CI) 1.01-1.43] 
      increase in the SA-VES. For participants with improved vitiligo, the MCID was 
      equal to a decrease in total SA-VES of 1.3% (95% CI 0.867-1.697). Patients' 
      perceptions of change in their vitiligo was increased sevenfold when it affected 
      the face vs. the rest of the body. CONCLUSIONS: Changes in the facial SA-VES were 
      highly correlated with patients' impressions of the extent of vitiligo.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of British 
      Association of Dermatologists. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Merhi, Samar
AU  - Merhi S
AD  - Universite Paris-Est Creteil, EpiDermE - Epidemiology in Dermatology and 
      Evaluation of Therapeutics, Creteil, France.
AD  - Faculty of Nursing and Health Sciences, Notre Dame University - Louaize (NDU), 
      Zouk Mosbeh, Lebanon.
FAU - Salameh, Pascale
AU  - Salameh P
AD  - School of Medicine, Lebanese American University, Byblos, Lebanon.
AD  - Institut National de Sante Publique d'Epidemiologie Clinique et de 
      Toxicologie-Liban (INSPECT-LB), Beirut, Lebanon.
AD  - Department of Primary Care and Population Health, University of Nicosia Medical 
      School, Nicosia, Cyprus.
AD  - Faculty of Pharmacy, Lebanese University, Hadat, Lebanon.
FAU - Abboud, Mounya
AU  - Abboud M
AD  - Universite Paris-Est Creteil, EpiDermE - Epidemiology in Dermatology and 
      Evaluation of Therapeutics, Creteil, France.
FAU - Seneschal, Julien
AU  - Seneschal J
AD  - University of Bordeaux, CNRS UMR5164, ImmunoConCept, Bordeaux, France.
AD  - Department of Dermatology, Pediatric Dermatology, National Reference Center for 
      Rare Skin Disorders, Hopital Saint-Andre, Bordeaux, France.
FAU - Eleftheriadou, Viktoria
AU  - Eleftheriadou V
AD  - Walsall Healthcare NHS Trust and The Royal Wolverhampton NHS Trust, University of 
      Birmingham, Birmingham, UK.
FAU - Pane, Isabelle
AU  - Pane I
AD  - Centre de Recherche Epidemiologie et StatistiqueS (CRESS - Universite Paris Cite, 
      INSERM UMR1153), Paris, France.
FAU - Tran, Viet-Thi
AU  - Tran VT
AD  - Centre de Recherche Epidemiologie et StatistiqueS (CRESS - Universite Paris Cite, 
      INSERM UMR1153), Paris, France.
AD  - Centre d'Epidemiologie Clinique - Hopital Hotel-Dieu (AP-HP), Paris, France.
FAU - Shourick, Jason
AU  - Shourick J
AD  - Department of Epidemiology and Public Health, UMR 1027 INSERM, Toulouse 
      University Hospital, Toulouse, France.
FAU - Ezzedine, Khaled
AU  - Ezzedine K
AD  - Universite Paris-Est Creteil, EpiDermE - Epidemiology in Dermatology and 
      Evaluation of Therapeutics, Creteil, France.
AD  - AP-HP, Hopital Henri-Mondor, Service de Dermatologie, Creteil, France.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Vitiligo/pathology
MH  - Cross-Sectional Studies
MH  - Surveys and Questionnaires
MH  - Severity of Illness Index
MH  - Perception
COIS- Conflicts of interest The authors declare they have no conflicts of interest.
EDAT- 2023/04/02 06:00
MHDA- 2023/07/19 06:42
CRDT- 2023/04/01 04:42
PHST- 2022/08/30 00:00 [received]
PHST- 2023/03/27 00:00 [revised]
PHST- 2023/03/29 00:00 [accepted]
PHST- 2023/07/19 06:42 [medline]
PHST- 2023/04/02 06:00 [pubmed]
PHST- 2023/04/01 04:42 [entrez]
AID - 7098435 [pii]
AID - 10.1093/bjd/ljad109 [doi]
PST - ppublish
SO  - Br J Dermatol. 2023 Jul 17;189(2):188-194. doi: 10.1093/bjd/ljad109.