PMID- 37004299
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230411
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1695
DP  - 2023 Apr 26
TI  - In-situ growth of covalent organic framework on stainless steel needles as 
      solid-phase microextraction probe coupled with electrospray ionization mass 
      spectrometry for rapid and sensitive determination of tricyclic antidepressants 
      in biosamples.
PG  - 463955
LID - S0021-9673(23)00181-4 [pii]
LID - 10.1016/j.chroma.2023.463955 [doi]
AB  - Tricyclic antidepressants (TCAs) including amitriptyline (AT), doxepin (DOX) and 
      nortriptyline (NT) are the first-line drugs for the clinical treatment of 
      depression; however, monitoring TCA concentrations in biological fluids and 
      tissues is necessary to improve therapeutic effect and determine the cause of 
      death in patients. It is of great significance to develop a rapid and sensitive 
      method for real-time monitoring of TCAs in various biosamples. In this work, we 
      fabricated a novel covalent organic framework (COF) based solid-phase 
      microextraction (SPME) probe by an in-situ step-by-step strategy, which was 
      obtained by sequentially modifying 1,3,5-tri (4-aminophenyl) benzene (TPB) and 2, 
      5-divinylbenzaldehyde (DVA) on the surface of polydopamine layer. The 
      TPB-DVA-COF-SPME probe possessed high specific surface area (1244 
      m(2).g (-) (1)), regular pores (3.23 nm), good hydrophobicity and stability, 
      resulting in efficient enrichment for TCAs. Furthermore, the combination of 
      TPB-DVA-COF-SPME probe and ambient electrospray ionization mass spectrometry 
      system (ESI/MS) was firstly proposed for rapid and sensitive determination of 
      TCAs in biosamples. As a result, the developed method exhibited low limits of 
      detection (LODs) (0.1-0.5 mug∙L (-) (1)), high enrichment factors (39-218), and 
      low relative standard deviations (RSDs) for one probe (1.2-3.8%) and 
      probe-to-probe (2.0-3.7%). Benefiting from these outstanding performance, 
      TPB-DVA-COF-SPME probe was further successfully applied to biosamples (i.e., 
      serum, liver, kidney, and brain) with excellent reusability, indicating the 
      promising applicability of the TPB-DVA-COF-SPME-ESI/MS as a powerful tool for 
      drug monitoring.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Yuan, Jiahao
AU  - Yuan J
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Huang, Weini
AU  - Huang W
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Tong, Wei
AU  - Tong W
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Chen, Zihan
AU  - Chen Z
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Li, Heming
AU  - Li H
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Chen, Jiajing
AU  - Chen J
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China.
FAU - Lin, Zian
AU  - Lin Z
AD  - Ministry of Education Key Laboratory of Analytical Science for Food Safety and 
      Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology 
      for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, 
      China. Electronic address: zianlin@fzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230328
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Metal-Organic Frameworks)
RN  - 12597-68-1 (Stainless Steel)
SB  - IM
MH  - Humans
MH  - *Antidepressive Agents, Tricyclic/analysis
MH  - Spectrometry, Mass, Electrospray Ionization/methods
MH  - *Metal-Organic Frameworks
MH  - Stainless Steel/chemistry
MH  - Solid Phase Microextraction/methods
MH  - Needles
OTO - NOTNLM
OT  - Covalent organic framework
OT  - Electrospray ionization mass spectrometry
OT  - Solid-phase microextraction
OT  - Tricyclic antidepressants
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/03 06:00
MHDA- 2023/04/11 06:42
CRDT- 2023/04/02 18:03
PHST- 2022/09/15 00:00 [received]
PHST- 2023/03/22 00:00 [revised]
PHST- 2023/03/27 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/04/03 06:00 [pubmed]
PHST- 2023/04/02 18:03 [entrez]
AID - S0021-9673(23)00181-4 [pii]
AID - 10.1016/j.chroma.2023.463955 [doi]
PST - ppublish
SO  - J Chromatogr A. 2023 Apr 26;1695:463955. doi: 10.1016/j.chroma.2023.463955. Epub 
      2023 Mar 28.