PMID- 37004703
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230722
IS  - 2240-2993 (Electronic)
IS  - 0300-9009 (Print)
IS  - 0300-9009 (Linking)
VI  - 123
IP  - 3
DP  - 2023 Jun
TI  - Efficacy and tolerability of lacosamide as adjunctive therapy in patients with 
      focal-onset seizures: an observational, prospective study.
PG  - 1081-1087
LID - 10.1007/s13760-023-02236-8 [doi]
AB  - PURPOSE: To evaluate the efficacy and tolerability of adjunctive lacosamide (LCM) 
      in patients with focal-onset seizures, with or without combined secondarily 
      generalized seizures. METHODS: 106 patients aged >/= 16 years were recruited 
      consecutively in this single-center prospective observational study. All patients 
      received LCM as an add-on treatment on the basis of clinical judgement. Seizure 
      frequency, adverse events (AEs) and retention rates were obtained at 3 and 
      6 months after LCM introduction. RESULT: The overall response rates were 53.3 and 
      70.4% after 3 and 6 months, respectively, and the freedom of seizures at the same 
      points was reached at 19 and 26.5%. The retention rates were 99.1% at the 3-month 
      follow-up and 93.3% at the 6-month follow-up. The overall incidence of adverse 
      events was 35.8%. The leading AEs were dizziness (16.98%) and sedation (6.6%). 
      CONCLUSIONS: Our study confirmed the efficacy and tolerability of adjunctive LCM 
      in Chinese patients in real-life conditions. Based on our treatment experience, a 
      universal maintenance dose of LCM would be needed in Chinese patients.
CI  - (c) 2023. The Author(s).
FAU - Jin, Yang
AU  - Jin Y
AD  - Department of Neurology, Qilu Hospital of Shandong University, Cheeloo College of 
      Medicine, 107 Jinan Culture Road, Jinan, 250012, Shandong, China.
FAU - Zhang, Ranran
AU  - Zhang R
AD  - Department of Neurology, Qilu Hospital of Shandong University, Cheeloo College of 
      Medicine, 107 Jinan Culture Road, Jinan, 250012, Shandong, China.
FAU - Jiang, Jing
AU  - Jiang J
AD  - Department of Neurology, Qilu Hospital of Shandong University, Cheeloo College of 
      Medicine, 107 Jinan Culture Road, Jinan, 250012, Shandong, China.
FAU - Liu, Xuewu
AU  - Liu X
AUID- ORCID: 0000-0002-9982-1065
AD  - Department of Neurology, Qilu Hospital of Shandong University, Cheeloo College of 
      Medicine, 107 Jinan Culture Road, Jinan, 250012, Shandong, China. 
      snlxw1966@163.com.
AD  - Institute of Epilepsy, Shandong University, Jinan, China. snlxw1966@163.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230401
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
RN  - 563KS2PQY5 (Lacosamide)
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Humans
MH  - Lacosamide
MH  - Prospective Studies
MH  - *Anticonvulsants/adverse effects
MH  - Treatment Outcome
MH  - *Seizures/drug therapy
MH  - Drug Therapy, Combination
PMC - PMC10066937
OTO - NOTNLM
OT  - Anti-seizure medication
OT  - Epilepsy
OT  - Focal seizures
OT  - Lacosamide
OT  - Seizure freedom
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/04/03 06:00
MHDA- 2023/06/05 06:42
PMCR- 2023/04/01
CRDT- 2023/04/02 19:01
PHST- 2022/09/19 00:00 [received]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/04/03 06:00 [pubmed]
PHST- 2023/04/02 19:01 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - 10.1007/s13760-023-02236-8 [pii]
AID - 2236 [pii]
AID - 10.1007/s13760-023-02236-8 [doi]
PST - ppublish
SO  - Acta Neurol Belg. 2023 Jun;123(3):1081-1087. doi: 10.1007/s13760-023-02236-8. 
      Epub 2023 Apr 1.