PMID- 37005959
OWN - NLM
STAT- MEDLINE
DCOM- 20230523
LR  - 20230524
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 35
IP  - 6
DP  - 2023 Jun
TI  - Prognostic significance of controlling nutritional status in older adults with 
      heart failure with preserved ejection fraction: a prospective comparative study 
      with other objective nutritional indices.
PG  - 1305-1315
LID - 10.1007/s40520-023-02395-x [doi]
AB  - OBJECTIVE: We explored the prognostic significance of controlling nutritional 
      status (CONUT) score in older adults with heart failure with preserved ejection 
      fraction (HFpEF) and compared CONUT with other objective nutritional indices. 
      METHODS: This is a single-center retrospective cohort study in older adult 
      coronary artery disease patients undergoing HFpEF. Clinical data and laboratory 
      results were collected before discharge. CONUT, geriatric nutritional risk index 
      (GNRI), and prognostic nutritional index (PNI) were calculated according to the 
      formula. The primary endpoint of this study was readmission due to heart failure 
      and all-cause mortality in the first year after hospitalization. RESULTS: A total 
      of 371 older adults were enrolled. All patients were discharged and followed up 
      for 1 year, and readmission for heart failure was 26% while all-cause mortality 
      was 20%. Compared with the none and mild malnutrition risk group, the readmission 
      rate for heart failure (HF) within 1 year (36% vs. 18%, 23%) and all-cause 
      mortality rate in the moderate and severe malnutrition risk group (40% vs. 8%, 
      0%) were higher (P < 0.05). On multivariate logistic analysis, CONUT was not 
      associated with readmission due to HF within 1 year. CONUT was significantly 
      associated with all-cause mortality independently of GNRI or PNI, after 
      adjustment for major confounders including age, bedridden; length of stay; 
      history of chronic kidney disease; loop diuretics use; angiotensin-converting 
      enzyme inhibitor/angiotensin receptor blocker and beta-adrenergic blocking agents 
      use; New York Heart Association (NYHA) functional class; hemoglobin; potassium; 
      Creatinine; triglycerides; glycosylated hemoglobin; brain natriuretic peptide; 
      left ventricular ejection fraction; GNRI and PNI via multivariable Cox analysis 
      (HR (95% CI) 1.764 (1.503, 2.071); 1.646 (1.359, 1.992); 1.764 (1.503, 2.071), 
      respectively). Kaplan-Meier analysis revealed that the risk of all-cause 
      mortality significantly increased in accordance with a higher CONUT (CONUT 5-12 
      compare to 0-1:HR (95% CI) 6.16 (3.78, 10.06); CONUT 2-4 compare to 0-1:HR (95% 
      CI) 0.16 (0.10, 0.26)). CONUT showed the best area under the curve value (0.789) 
      for the prediction of all-cause mortality compared with the other objective 
      nutritional indices. CONCLUSION: CONUT is a simple and strong prognostic 
      indicator for the prediction of all-cause mortality in older adults with HFpEF. 
      GOV IDENTIFIER: NCT05586828.
CI  - (c) 2023. The Author(s).
FAU - Chen, Ying
AU  - Chen Y
AUID- ORCID: 0000-0002-8116-6453
AD  - Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, 100730, China. trchenying@mail.ccmu.edu.cn.
FAU - Zheng, Hui
AU  - Zheng H
AD  - Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, 100730, China.
FAU - He, Yu
AU  - He Y
AD  - Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, 100730, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT05586828
PT  - Journal Article
DEP - 20230401
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Humans
MH  - Aged
MH  - Nutritional Status
MH  - Nutrition Assessment
MH  - Prognosis
MH  - *Heart Failure/complications
MH  - Stroke Volume/physiology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Ventricular Function, Left
MH  - *Malnutrition/complications
PMC - PMC10200784
OTO - NOTNLM
OT  - Aged
OT  - Heart failure with preserved ejection fraction
OT  - Nutritional status control
OT  - Prognosis
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/04/04 06:00
MHDA- 2023/05/23 06:42
PMCR- 2023/04/01
CRDT- 2023/04/03 02:44
PHST- 2022/11/13 00:00 [received]
PHST- 2023/03/17 00:00 [accepted]
PHST- 2023/05/23 06:42 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 02:44 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - 10.1007/s40520-023-02395-x [pii]
AID - 2395 [pii]
AID - 10.1007/s40520-023-02395-x [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2023 Jun;35(6):1305-1315. doi: 10.1007/s40520-023-02395-x. 
      Epub 2023 Apr 1.