PMID- 37006070
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230404
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 19
IP  - 2
DP  - 2023 Jan-Mar
TI  - Frequency and pattern of chromosomal abnormalities in acute myeloid leukemia from 
      Western India: A retrospective study.
PG  - 340-346
LID - 10.4103/jcrt.jcrt_393_22 [doi]
AB  - CONTEXT: Chromosomal abnormalities play an important role in diagnosis and 
      prognosis of hematological diseases. AIMS: The aim of the present study was to 
      study the pattern and frequency of chromosomal aberrations in acute myeloid 
      leukemia (AML) subgroups from western India. SETTINGS AND DESIGN: A retrospective 
      study was conducted through evaluating laboratory proforma which were filled 
      during 2005 to 2014 for diagnosis and treatment of AML subjects. METHODS AND 
      MATERIAL: We have studied chromosomal aberrations in 282 subjects with AML from 
      western India. AML patients were sub-grouped according to FAB classification. 
      Cytogenetic study using conventional cytogenetics (GTG-banding) and Fluorescence 
      in situ hybridization (FISH) was carried out using FISH probes (AML1/ETO, 
      PML/RARA, CBFB). STATISTICAL ANALYSIS: Student's t test for continuous variables 
      and Pearson's Chi-squared test for categorical variables were used to identify 
      the relationship between variables. RESULTS: Cytomorphological study revealed 
      AML- M3 as most frequent (32.3%) group followed by AML-M2 (25.2%) and AML-M4 
      (19.9%). Chromosomal abnormalities were identified in 145 (51.42%) of the total 
      AML cases. A high frequency (38.6%) of chromosomal abnormalities was identified 
      in AML-M3 subgroup as compared to AML-M2 (31%) and AML-M4 (20.6%). CONCLUSIONS: 
      Cytogenetic study is important for the diagnosis and management of the AML 
      patients. Our study identified chromosomal abnormalities in AML subgroups with 
      varied frequencies. It is important in diagnosis and monitoring of the disease. 
      As younger AML patients were more affected in our study, etiological factors such 
      as environmental factors need to be studied. Combination of conventional 
      cytogenetics and FISH has an advantage of identifying high frequency of 
      chromosomal aberrations in AML patients.
FAU - Vundinti, Babu Rao
AU  - Vundinti BR
AD  - Department of Cytogenetics, National Institute of Immunohematology (ICMR), K.E.M 
      Hospital Campus, Parel, Mumbai, Maharashtra, India.
FAU - Korgaonkar, Seema
AU  - Korgaonkar S
AD  - Department of Cytogenetics, National Institute of Immunohematology (ICMR), K.E.M 
      Hospital Campus, Parel, Mumbai, Maharashtra, India.
FAU - Dhangar, Somprakash
AU  - Dhangar S
AD  - Department of Cytogenetics, National Institute of Immunohematology (ICMR), K.E.M 
      Hospital Campus, Parel, Mumbai, Maharashtra, India.
FAU - Jijina, Farah
AU  - Jijina F
AD  - Department of Haematology, KEM Hospital, Parel, Mumbai, Maharashtra, India.
FAU - Shanmukhaiah, Chandrakala
AU  - Shanmukhaiah C
AD  - Department of Haematology, KEM Hospital, Parel, Mumbai, Maharashtra, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping
MH  - *Chromosome Aberrations
MH  - *Leukemia, Myeloid, Acute/diagnosis/epidemiology/genetics
MH  - India/epidemiology
OTO - NOTNLM
OT  - AML-M3
OT  - Acute myeloid leukemia
OT  - chromosomal aberrations
OT  - cytogenetics
OT  - western Indian population
EDAT- 2023/04/04 06:00
MHDA- 2023/04/04 06:42
CRDT- 2023/04/03 02:49
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/04/03 02:49 [entrez]
PHST- 2023/04/04 06:00 [pubmed]
AID - JCanResTher_2023_19_2_340_371870 [pii]
AID - 10.4103/jcrt.jcrt_393_22 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2023 Jan-Mar;19(2):340-346. doi: 10.4103/jcrt.jcrt_393_22.