PMID- 37006132
OWN - NLM
STAT- MEDLINE
DCOM- 20231121
LR  - 20231121
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 94
IP  - 10
DP  - 2023 Oct
TI  - Gingival crevicular fluid periodontal ligament-associated protein-1, sclerostin, 
      and tumor necrosis factor-alpha levels in periodontitis.
PG  - 1166-1175
LID - 10.1002/JPER.22-0750 [doi]
AB  - BACKGROUND: In periodontitis, the equilibrium between bone formation and 
      resorption skews in favor of bone loss. Periodontal ligament-associated protein-1 
      (PLAP-1) and sclerostin play a significant role in the suppression of bone 
      formation. Tumor necrosis factor-alpha (TNF-alpha) is a central proinflammatory 
      cytokine related to periodontal bone loss. This study aims to assess gingival 
      crevicular fluid (GCF) PLAP-1, sclerostin, and TNF-alpha levels in individuals with 
      periodontal disease. METHODS: Seventy-one individuals diagnosed with generalized 
      stage III grade C periodontitis (n = 23), gingivitis (n = 24), and periodontal 
      health (n = 24) were included in the study. Full-mouth clinical periodontal 
      measurements were performed. PLAP-1, sclerostin, and TNF-alpha total amounts in GCF 
      were quantified by ELISA. Nonparametric methods were used for the data analyses. 
      RESULTS: Periodontitis group exhibited significantly higher GCF PLAP-1, 
      sclerostin and TNF-alpha levels compared with gingivitis and periodontally healthy 
      groups (p < 0.05). GCF PLAP-1 and TNF-alpha levels of gingivitis group were higher 
      than healthy controls (p < 0.05) whereas GCF sclerostin levels were similar in 
      two groups (p > 0.05). Significant positive correlations were found between GCF 
      PLAP-1, sclerostin and TNF-alpha levels and all clinical parameters (p < 0.01). 
      CONCLUSIONS: To our knowledge, this is the first study showing GCF PLAP-1 levels 
      in periodontal health and disease. Increased GCF PLAP-1 and sclerostin levels and 
      their correlations with TNF-alpha in periodontitis imply that those molecules might 
      be involved in the pathogenesis of periodontal disease. Further studies in larger 
      mixed cohorts are needed to enlighten the possible role of PLAP-1 and sclerostin 
      in periodontal bone loss.
CI  - (c) 2023 The Authors. Journal of Periodontology published by Wiley Periodicals LLC 
      on behalf of American Academy of Periodontology.
FAU - Gur, Berkay
AU  - Gur B
AD  - Department of Periodontology, Faculty of Dentistry, Aydin Adnan Menderes 
      University, Aydin, Turkey.
FAU - Afacan, Beral
AU  - Afacan B
AD  - Department of Periodontology, Faculty of Dentistry, Aydin Adnan Menderes 
      University, Aydin, Turkey.
FAU - Cevik, Ozge
AU  - Cevik O
AD  - Department of Biochemistry, School of Medicine, Aydin Adnan Menderes University, 
      Aydin, Turkey.
FAU - Kose, Timur
AU  - Kose T
AD  - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Izmir 
      Ege University, Izmir, Turkey.
FAU - Emingil, Gulnur
AU  - Emingil G
AD  - Department of Periodontology, Faculty of Dentistry, Izmir Ege University, Izmir, 
      Turkey.
LA  - eng
SI  - ClinicalTrials.gov/NCT05656989
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230419
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (ASPN protein, human)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (SOST protein, human)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Adaptor Proteins, Signal Transducing/analysis/genetics/metabolism
MH  - *Alveolar Bone Loss/etiology/genetics/metabolism
MH  - *Chronic Periodontitis/complications/genetics/metabolism
MH  - *Extracellular Matrix Proteins/analysis/genetics/metabolism
MH  - *Gingival Crevicular Fluid/chemistry
MH  - Gingivitis/complications/genetics/metabolism
MH  - *Tumor Necrosis Factor-alpha/analysis/genetics/metabolism
OTO - NOTNLM
OT  - alveolar bone loss
OT  - cytokines
OT  - gingival crevicular fluid
OT  - inflammation
OT  - periodontitis
EDAT- 2023/04/04 06:00
MHDA- 2023/10/23 00:43
CRDT- 2023/04/03 03:03
PHST- 2023/03/27 00:00 [revised]
PHST- 2022/12/30 00:00 [received]
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/10/23 00:43 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 03:03 [entrez]
AID - 10.1002/JPER.22-0750 [doi]
PST - ppublish
SO  - J Periodontol. 2023 Oct;94(10):1166-1175. doi: 10.1002/JPER.22-0750. Epub 2023 
      Apr 19.