PMID- 37006496 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230404 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 14 DP - 2023 TI - Clinical effect of short-term spinal cord stimulation in the treatment of patients with primary brainstem hemorrhage-induced disorders of consciousness. PG - 1124871 LID - 10.3389/fneur.2023.1124871 [doi] LID - 1124871 AB - OBJECTIVE: Recently, short-term spinal cord stimulation (st-SCS) has been used in neurorehabilitation and consciousness recovery. However, little is known about its effects on primary brainstem hemorrhage (PBSH)-induced disorders of consciousness (DOC). In this study, we examined the therapeutic effects of st-SCS in patients with PBSH-induced DOC. METHODS: Fourteen patients received a 2-week st-SCS therapy. Each patient's state of consciousness was evaluated using the Coma Recovery Scale-Revised (CRS-R). CRS-R evaluation scores were recorded at the baseline (before SCS implantation) and 14 days later. RESULTS: Over 70% (10/14) of the patients (CRS-R score increased to >/=2 points) responded to the SCS stimulation after 14 days of st-SCS treatment. All items included in the CRS-R exhibited a significant increase post-treatment compared with pretreatment. After 2 weeks of st-SCS treatment, seven patients showed diagnostic improvement, resulting in a 50% (7/14) overall effective rate. Approximately 75% (3/4) of patients with minimally conscious state plus (MCS+) improved to emergence from MCS (eMCS), and 50% (1/2) of patients with vegetative state or unresponsive wakefulness syndrome (VS/UWS) improved to MCS+. CONCLUSION: In PBSH-induced DOC, st-SCS is a safe and effective treatment. The clinical behavior of the patients improved significantly following the st-SCS intervention, and their CRS-R scores markedly increased. This was most effective for MCS+. CI - Copyright (c) 2023 Huang, Chen, Liu, Tang, Zhou, Tang, Jiang, Li, Liu and Wang. FAU - Huang, Weilong AU - Huang W AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Chen, Qiang AU - Chen Q AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Liu, Lin AU - Liu L AD - Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou, China. FAU - Tang, Jianhong AU - Tang J AD - Laboratory Animal Engineering Research Center of Ganzhou, Gannan Medical University, Ganzhou, China. FAU - Zhou, Hua AU - Zhou H AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Tang, Zhiji AU - Tang Z AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Jiang, Qing AU - Jiang Q AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Li, Tao AU - Li T AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Liu, Jianwu AU - Liu J AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. FAU - Wang, Dong AU - Wang D AD - Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, China. LA - eng PT - Journal Article DEP - 20230317 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC10064090 OTO - NOTNLM OT - disorder of consciousness OT - minimally conscious state OT - neuromodulation OT - primary brainstem hemorrhage OT - short-term spinal cord stimulation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/04/04 06:00 MHDA- 2023/04/04 06:01 PMCR- 2023/03/17 CRDT- 2023/04/03 03:48 PHST- 2022/12/15 00:00 [received] PHST- 2023/02/23 00:00 [accepted] PHST- 2023/04/04 06:01 [medline] PHST- 2023/04/03 03:48 [entrez] PHST- 2023/04/04 06:00 [pubmed] PHST- 2023/03/17 00:00 [pmc-release] AID - 10.3389/fneur.2023.1124871 [doi] PST - epublish SO - Front Neurol. 2023 Mar 17;14:1124871. doi: 10.3389/fneur.2023.1124871. eCollection 2023.