PMID- 37008205 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230404 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 17 DP - 2023 TI - Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation. PG - 1125677 LID - 10.3389/fnins.2023.1125677 [doi] LID - 1125677 AB - PURPOSE: Investigating the changes of regional homogeneity (ReHo) values and both static and dynamic functional connectivity (FC) before and after Traditional Chinese Manual Therapy (Tuina) in patients with lumbar disk herniation (LDH) through resting-state functional magnetic resonance imaging (RS-fMRI). Based on this, we observe the effect of Tuina on the above abnormal changes. METHODS: Patients with LDH (n = 27) and healthy controls (HCs) (n = 28) were recruited. The functional magnetic resonance imaging (fMRI) scanning was performed two times in LDH patients, before Tuina (time point 1, LDH-pre) and after the sixth Tuina (time point 2, LDH-pos). And for one time in HCs which received no intervention. The ReHo values were compared between LDH-pre and HCs. The significant clusters detected by ReHo analysis were selected as seeds to calculate static functional connectivity (sFC). We also applied the sliding-window to perform dynamic functional connectivity (dFC). To evaluate the Tuina effect, the mean ReHo and FC values (both static and dynamic) were extracted from significant clusters and compared between LDH and HCs. RESULTS: In comparison to HCs, LDH patients displayed decreased ReHo in the left orbital part middle frontal gyrus (LO-MFG). For sFC analysis, no significant difference was found. However, we found decreased dFC variance between LO-MFG and the left Fusiform, and increased dFC variance in the left orbital inferior frontal gyrus and left precuneus. Both ReHo and dFC values revealed after Tuina, the brain activities in LDH patients were similar to HCs. CONCLUSION: The present study characterized the altered patterns of regional homogeneity in spontaneous brain activity and those of functional connectivity in patients with LDH. Tuina can reshape the function of the default mode network (DMN) in LDH patients, which may contribute to the analgesic effect of Tuina in LDH patients. CI - Copyright (c) 2023 Chen, Wen, Chen, Jin, Liu, Wang, Kong, Ling, Huang, Chai, Zhao, Li, Xu, Jiang and Du. FAU - Chen, Xiao-Min AU - Chen XM AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Wen, Ya AU - Wen Y AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Chen, Shao AU - Chen S AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Jin, Xin AU - Jin X AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Liu, Chen AU - Liu C AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Wang, Wei AU - Wang W AD - Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Kong, Ning AU - Kong N AD - Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Ling, Dong-Ya AU - Ling DY AD - Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Huang, Qin AU - Huang Q AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Chai, Jin-Er AU - Chai JE AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Zhao, Xiao-Lei AU - Zhao XL AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Li, Jie AU - Li J AD - Department of Radiology, Changshu No.2 People's Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China. FAU - Xu, Mao-Sheng AU - Xu MS AD - Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Jiang, Zhong AU - Jiang Z AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. FAU - Du, Hong-Gen AU - Du HG AD - Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. LA - eng PT - Journal Article DEP - 20230315 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 PMC - PMC10050335 OTO - NOTNLM OT - Tuina OT - functional connectivity OT - lumbar disc herniation OT - regional homogeneity OT - resting-state fMRI COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/04/04 06:00 MHDA- 2023/04/04 06:01 PMCR- 2023/01/01 CRDT- 2023/04/03 04:08 PHST- 2022/12/16 00:00 [received] PHST- 2023/02/24 00:00 [accepted] PHST- 2023/04/04 06:01 [medline] PHST- 2023/04/03 04:08 [entrez] PHST- 2023/04/04 06:00 [pubmed] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fnins.2023.1125677 [doi] PST - epublish SO - Front Neurosci. 2023 Mar 15;17:1125677. doi: 10.3389/fnins.2023.1125677. eCollection 2023.