PMID- 37009413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230404
IS  - 2688-2663 (Electronic)
IS  - 2688-2663 (Linking)
VI  - 4
IP  - 2
DP  - 2023 Apr
TI  - Genome-wide association study of tuberculosis in the western Chinese Han and 
      Tibetan population.
PG  - e250
LID - 10.1002/mco2.250 [doi]
LID - e250
AB  - Tuberculosis (TB) remains a serious global public health threat. Accumulated 
      evidence has demonstrated that human susceptibility to TB has a strong genetic 
      basis. And different susceptibility single nucleotide polymorphisms (SNP) have 
      been reported in different studies. To gain greater insight into the host 
      susceptibility to TB, we perform a two-stage genome-wide association study to 
      identify the susceptible loci of TB. In the discovery stage, 3116 (1532 TB 
      patients and 1584 healthy controls) and 439 (211 TB patients and 228 healthy 
      controls) individuals were genome-wide genotyped from a western Chinese Han and 
      Tibetan population, respectively. Based on the additive genetic model, we 
      discovered 14 and three independent loci that had potential associations with TB 
      susceptibility in the Chinese Han and Tibetan populations, respectively 
      (p < 1 x 10(-5)). Furthermore, we conducted an imputation-based meta-analysis on 
      another two East Asia cohorts to replicate our findings. We identified one 
      independent locus harbored by the human leukocyte antigen (HLA) class II genes 
      that was genome-wide significantly associated with TB (lead SNP rs111875628 with 
      a p-value of 2.20 x 10(-9)). Our findings suggest a novel mechanism of the 
      interaction with the HLA class II genes and reinforce the importance of the HLA 
      class II alleles in response to TB.
CI  - (c) 2023 The Authors. MedComm published by Sichuan International Medical Exchange & 
      Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
FAU - Bai, Hao
AU  - Bai H
AUID- ORCID: 0000-0002-0916-5755
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Song, Mengyuan
AU  - Song M
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Lei, Shikun
AU  - Lei S
AD  - State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan 
      University Chengdu P. R. China.
FAU - Jiao, Lin
AU  - Jiao L
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Hu, Xuejiao
AU  - Hu X
AD  - Division of Laboratory Medicine Guangdong Provincial People's Hospital Guangdong 
      Academy of Medical Sciences Guangzhou P. R. China.
FAU - Wu, Tao
AU  - Wu T
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Song, Jiajia
AU  - Song J
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Liu, Tangyuheng
AU  - Liu T
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Peng, Wu
AU  - Peng W
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Zhao, Zhenzhen
AU  - Zhao Z
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Meng, Zirui
AU  - Meng Z
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
FAU - Ying, Binwu
AU  - Ying B
AD  - Department of Laboratory Medicine West China Hospital Sichuan University Chengdu 
      P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20230329
PL  - China
TA  - MedComm (2020)
JT  - MedComm
JID - 101769925
PMC - PMC10050958
OTO - NOTNLM
OT  - genome-wide association study
OT  - human leukocyte antigen
OT  - susceptibility
OT  - tuberculosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/04 06:00
MHDA- 2023/04/04 06:01
PMCR- 2023/03/29
CRDT- 2023/04/03 04:26
PHST- 2022/11/13 00:00 [received]
PHST- 2023/02/16 00:00 [revised]
PHST- 2023/03/03 00:00 [accepted]
PHST- 2023/04/04 06:01 [medline]
PHST- 2023/04/03 04:26 [entrez]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - MCO2250 [pii]
AID - 10.1002/mco2.250 [doi]
PST - epublish
SO  - MedComm (2020). 2023 Mar 29;4(2):e250. doi: 10.1002/mco2.250. eCollection 2023 
      Apr.