PMID- 37009789
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230514
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 45
IP  - 6
DP  - 2023 Jun
TI  - Tumor volume as a predictor of survival in advanced laryngeal cancer treated with 
      total laryngectomy.
PG  - 1376-1388
LID - 10.1002/hed.27351 [doi]
AB  - BACKGROUND: Recent literature shows that tumor volume (TV) in T3 laryngeal 
      squamous cell carcinoma (LSCC) is associated with response to radiation therapy. 
      The aim of this study was to evaluate the effect of TV on survival outcomes in 
      patients undergoing total laryngectomy (TL). METHODS: One hundred and seventeen 
      patients with LSCC undergoing TL between 2013 and 2020 at the University of 
      Florida were included. TV was measured using a previously validated method on 
      preoperative-CT scans. Multivariable CoxPH models for overall survival (OS) and 
      disease-specific survival (DSS), metastasis-free survival (MFS), and 
      recurrence-free survival (RFS) were developed with TV. RESULTS: Mean age was 
      61.5 years and 81.2% were male. Higher TV was associated with decreased OS, MFS, 
      DSS, and RFS with adjusted hazard ratios 1.02 (95%CI: 1.01, 1.03), 1.01, (95%CI: 
      1.00, 1.03), 1.03 (95%CI: 1.01, 1.06), and 1.02 (95%CI: 1.00, 1.03) respectively. 
      TV >7.1 cc had worse prognoses. CONCLUSIONS: TV appears associated with decreased 
      survival in LSCC treated with TL.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Hanubal, Krishna S
AU  - Hanubal KS
AUID- ORCID: 0000-0001-6825-9551
AD  - College of Medicine, University of Florida, Gainesville, Florida, USA.
FAU - Galochkina, Zhanna
AU  - Galochkina Z
AD  - Division of Quantitative Sciences, University of Florida Health Cancer Center, 
      Gainesville, Florida, USA.
FAU - Lee, Ji-Hyun
AU  - Lee JH
AD  - Division of Quantitative Sciences, University of Florida Health Cancer Center, 
      Gainesville, Florida, USA.
AD  - Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
FAU - List, Marna A
AU  - List MA
AD  - College of Medicine, University of Florida, Gainesville, Florida, USA.
FAU - Massini, Tara C
AU  - Massini TC
AD  - Department of Radiology, University of Florida, Gainesville, Florida, USA.
FAU - Conrad, Dustin
AU  - Conrad D
AD  - Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
FAU - Hughley, Brian
AU  - Hughley B
AD  - Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
FAU - Danan, Deepa
AU  - Danan D
AD  - Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
FAU - DeJesus, Reordan
AU  - DeJesus R
AD  - Department of Radiology, University of Florida, Gainesville, Florida, USA.
FAU - Hitchcock, Kathryn
AU  - Hitchcock K
AD  - Department of Radiation Oncology, University of Florida, Gainesville, Florida, 
      USA.
AD  - University of Florida Health Cancer Center, Gainesville, Florida, USA.
FAU - Nichols, Spencer
AU  - Nichols S
AUID- ORCID: 0000-0003-4657-7844
AD  - College of Medicine, University of Florida, Gainesville, Florida, USA.
FAU - Mendenhall, William
AU  - Mendenhall W
AUID- ORCID: 0000-0002-6592-2810
AD  - Department of Radiation Oncology, University of Florida, Gainesville, Florida, 
      USA.
AD  - University of Florida Health Cancer Center, Gainesville, Florida, USA.
FAU - Dziegielewski, Peter T
AU  - Dziegielewski PT
AD  - Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
AD  - University of Florida Health Cancer Center, Gainesville, Florida, USA.
LA  - eng
PT  - Journal Article
DEP - 20230403
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Female
MH  - *Laryngeal Neoplasms/pathology
MH  - Laryngectomy/methods
MH  - Tumor Burden
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - *Head and Neck Neoplasms/pathology
MH  - Neoplasm Staging
OTO - NOTNLM
OT  - laryngeal cancer
OT  - laryngectomy
OT  - radiation therapy
OT  - survival outcomes
OT  - tumor volume
EDAT- 2023/04/04 06:00
MHDA- 2023/05/12 07:06
CRDT- 2023/04/03 05:34
PHST- 2023/03/08 00:00 [revised]
PHST- 2022/08/26 00:00 [received]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/05/12 07:06 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 05:34 [entrez]
AID - 10.1002/hed.27351 [doi]
PST - ppublish
SO  - Head Neck. 2023 Jun;45(6):1376-1388. doi: 10.1002/hed.27351. Epub 2023 Apr 3.