PMID- 37009872
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20230522
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 21
IP  - 1
DP  - 2023 Apr 2
TI  - The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes 
      mellitus.
PG  - 240
LID - 10.1186/s12967-023-04088-5 [doi]
LID - 240
AB  - Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable 
      diseases (NCDs), is a systemic inflammatory disease characterized by 
      dysfunctional pancreatic beta-cells and/or peripheral insulin resistance, resulting 
      in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, 
      and sociodemographic factors are known as related to high T2DM risk. Dietary 
      lipids and lipid metabolism are significant metabolic modulators in T2DM and 
      T2DM-related complications. Besides, accumulated evidence suggests that altered 
      gut microbiota which plays an important role in the metabolic health of the host 
      contributes significantly to T2DM involving impaired or improved glucose and 
      lipid metabolism. At this point, dietary lipids may affect host physiology and 
      health via interaction with the gut microbiota. Besides, increasing evidence in 
      the literature suggests that lipidomics as novel parameters detected with 
      holistic analytical techniques have important roles in the pathogenesis and 
      progression of T2DM, through various mechanisms of action including gut-brain 
      axis modulation. A better understanding of the roles of some nutrients and 
      lipidomics in T2DM through gut microbiota interactions will help develop new 
      strategies for the prevention and treatment of T2DM. However, this issue has not 
      yet been entirely discussed in the literature. The present review provides 
      up-to-date knowledge on the roles of dietary lipids and lipidomics in gut-brain 
      axis in T2DM and some nutritional strategies in T2DM considering lipids- 
      lipidomics and gut microbiota interactions are given.
CI  - (c) 2023. The Author(s).
FAU - Agagunduz, Duygu
AU  - Agagunduz D
AUID- ORCID: 0000-0003-0010-0012
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi 
      University, 06490, Ankara, Turkey. duyguturkozu@gazi.edu.tr.
FAU - Icer, Mehmet Arif
AU  - Icer MA
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Amasya 
      University, 05100, Amasya, Turkey.
FAU - Yesildemir, Ozge
AU  - Yesildemir O
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bursa Uludag 
      University, 16059, Bursa, Turkey.
FAU - Kocak, Tevfik
AU  - Kocak T
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi 
      University, 06490, Ankara, Turkey.
FAU - Kocyigit, Emine
AU  - Kocyigit E
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ordu 
      University, 52200, Ordu, Turkey.
FAU - Capasso, Raffaele
AU  - Capasso R
AD  - Department of Agricultural Sciences, University of Naples Federico II, Portici, 
      80055, Naples, Italy. rafcapas@unina.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230402
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Brain-Gut Axis
MH  - Lipidomics
MH  - Glucose
MH  - Dietary Fats
PMC - PMC10068184
OTO - NOTNLM
OT  - Diet
OT  - Gut microbiota
OT  - Lipidomics
OT  - Lipids
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2023/04/04 06:00
MHDA- 2023/04/04 06:42
PMCR- 2023/04/02
CRDT- 2023/04/03 06:03
PHST- 2023/02/20 00:00 [received]
PHST- 2023/03/25 00:00 [accepted]
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/04/03 06:03 [entrez]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/02 00:00 [pmc-release]
AID - 10.1186/s12967-023-04088-5 [pii]
AID - 4088 [pii]
AID - 10.1186/s12967-023-04088-5 [doi]
PST - epublish
SO  - J Transl Med. 2023 Apr 2;21(1):240. doi: 10.1186/s12967-023-04088-5.