PMID- 37010242
OWN - NLM
STAT- MEDLINE
DCOM- 20231010
LR  - 20231018
IS  - 1099-1069 (Electronic)
IS  - 0278-0232 (Linking)
VI  - 41
IP  - 4
DP  - 2023 Oct
TI  - Refining prognosis in chronic lymphocytic leukemia with normal Fluorescence in 
      situ hybridization results.
PG  - 771-775
LID - 10.1002/hon.3134 [doi]
AB  - Fluorescence in situ hybridization (FISH) to detect the recurrent cytogenetics 
      abnormalities deletion 13q, trisomy 12, deletion 11q, and deletion 17p is 
      important for prognostication in chronic lymphocytic leukemia (CLL). A subset of 
      patients are negative for each of these abnormalities (normal 12/13/11/17 FISH), 
      and outcomes are heterogenous within this group. To elucidate variables important 
      for prognostication in this subgroup we conducted a retrospective analysis of 280 
      treatment-naive CLL patients with normal standard CLL FISH results. In a 
      multivariable model, advanced Rai stage (p = 0.04, hazard ratio [HR] 1.24 (95% 
      confidence interval [CI] 1.01-1.53)), unmutated immunoglobulin heavy chain gene 
      (IGHV) (p < 0.0001, HR 5.59 (95% CI 3.63-8.62)) and IGH rearrangement by FISH 
      (p = 0.02, HR 2.56 (95% CI 1.20-5.48)) were significantly associated with shorter 
      time to first treatment. In a multivariable model for overall survival, 
      increasing age at 5-year increments (p < 0.0001, HR 1.55 (95% CI 1.25-1.93)), 
      unmutated IGHV (p = 0.01, HR 5.28 (95% CI 1.52-18.35)) and gain of REL (p = 0.01, 
      HR 4.08 (5% CI 1.45-11.49)) were significantly associated with shorter survival. 
      Our study identifies variables important for refining prognosis for CLL patients 
      with normal standard CLL FISH results.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Avenarius, Matthew R
AU  - Avenarius MR
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Huang, Ying
AU  - Huang Y
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Hyak, Jonathan
AU  - Hyak J
AUID- ORCID: 0000-0001-7039-0655
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Byrd, John C
AU  - Byrd JC
AD  - Department of Internal Medicine, The University of Cincinnati, Cincinnati, Ohio, 
      USA.
FAU - Bhat, Seema A
AU  - Bhat SA
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Grever, Michael
AU  - Grever M
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Kittai, Adam S
AU  - Kittai AS
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Rogers, Kerry A
AU  - Rogers KA
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Jones, Dan
AU  - Jones D
AUID- ORCID: 0000-0002-4688-3780
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Zhao, Weiqiang
AU  - Zhao W
AUID- ORCID: 0000-0001-6560-2780
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Heerema, Nyla A
AU  - Heerema NA
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Abruzzo, Lynne V
AU  - Abruzzo LV
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Woyach, Jennifer
AU  - Woyach J
AD  - Division of Hematology, Department of Internal Medicine, College of Medicine, The 
      Ohio State University, Columbus, Ohio, USA.
FAU - Miller, Cecelia R
AU  - Miller CR
AUID- ORCID: 0000-0001-6110-6069
AD  - Department of Pathology, College of Medicine, The Ohio State University, 
      Columbus, Ohio, USA.
LA  - eng
PT  - Letter
DEP - 20230403
PL  - England
TA  - Hematol Oncol
JT  - Hematological oncology
JID - 8307268
SB  - IM
MH  - Humans
MH  - Child, Preschool
MH  - In Situ Hybridization, Fluorescence/methods
MH  - *Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/genetics
MH  - Retrospective Studies
MH  - Chromosome Aberrations
MH  - Prognosis
OTO - NOTNLM
OT  - IGHV
OT  - chronic lymphocytic leukemia
OT  - fluorescence in situ hybridization
EDAT- 2023/04/04 06:00
MHDA- 2023/10/10 06:41
CRDT- 2023/04/03 08:42
PHST- 2023/10/10 06:41 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 08:42 [entrez]
AID - 10.1002/hon.3134 [doi]
PST - ppublish
SO  - Hematol Oncol. 2023 Oct;41(4):771-775. doi: 10.1002/hon.3134. Epub 2023 Apr 3.