PMID- 37010560
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230517
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 415
IP  - 14
DP  - 2023 Jun
TI  - Development of dispersive liquid-liquid microextraction with solid-phase 
      evaporation as a novel hyphenated method prior to ion mobility spectrometry and 
      its application for trace analysis of fluoxetine.
PG  - 2665-2676
LID - 10.1007/s00216-023-04665-z [doi]
AB  - For the hyphenating of dispersive liquid-liquid microextraction (DLLME) with nano 
      mesoporous solid-phase evaporation (SPE(V)) as a novel method, MCM-41@SiO(2) was 
      synthesized and used as a nano mesoporous adsorbent for coating on the 
      solid-phase fiber, preconcentration of fluoxetine antidepressant drug (as a model 
      compound), and total evaporation of the extraction solvents obtained by the DLLME 
      method. To detect the analyte molecules, a corona discharge ionization-ion 
      mobility spectrometer (CD-IMS) was applied. In order to increase the extraction 
      efficiency and the IMS signal of the fluoxetine drug, some variables including 
      extraction solvent and its volume, disperser solvents and its volume, sample 
      solution pH, desorption temperature, and evaporation time of the solvent from the 
      solid-phase fiber were chosen and optimized. Some analytical parameters including 
      limit of detection (LOD), limit of quantification (LOQ), linear dynamic range 
      (LDR) with determination coefficient, and relative standard deviations (RSDs) 
      were calculated under the optimized conditions. LOD (S/N = 3), 3 ng mL(-1); LOQ 
      (S/N = 10), 10 ng mL(-1); LDR, 10-200 ng mL(-1); and intra- and inter-day RSDs 
      (n = 3), 2.5% and 9.6% for 10 ng mL(-1), and 1.8% and 7.7% for 150 ng mL(-1), 
      respectively. To investigate the ability of the hyphenated method to determine 
      fluoxetine in real samples, fluoxetine tablets, and some biological samples such 
      as human urine and blood plasma were selected and the relative recovery values 
      were calculated to be 85-110%. The accuracy of the proposed method was compared 
      with that of the HPLC standard method.
CI  - (c) 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Azadkish, Kamal
AU  - Azadkish K
AD  - Department of Chemistry, Yasouj University, Yasouj, 7591874831, Iran.
FAU - Shokrollahi, Ardeshir
AU  - Shokrollahi A
AD  - Department of Chemistry, Yasouj University, Yasouj, 7591874831, Iran. 
      ashokrollahi@yu.ac.ir.
FAU - Rezayat, Mohammad Reza
AU  - Rezayat MR
AD  - Department of Chemistry, Yasouj University, Yasouj, 7591874831, Iran.
FAU - Rastgar, Mahdi
AU  - Rastgar M
AD  - Department of Chemistry, Yasouj University, Yasouj, 7591874831, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230403
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 01K63SUP8D (Fluoxetine)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 0 (Solvents)
SB  - IM
MH  - Humans
MH  - *Fluoxetine
MH  - Silicon Dioxide
MH  - Ion Mobility Spectrometry
MH  - *Liquid Phase Microextraction/methods
MH  - Solvents/chemistry
MH  - Limit of Detection
OTO - NOTNLM
OT  - Dispersive liquid-liquid microextraction
OT  - Fluoxetine antidepressant drug
OT  - MCM-41@SiO2
OT  - Microextraction
OT  - Solid-phase evaporation
OT  - Solvent removal
EDAT- 2023/04/04 06:00
MHDA- 2023/05/17 06:42
CRDT- 2023/04/03 11:13
PHST- 2022/12/31 00:00 [received]
PHST- 2023/03/20 00:00 [accepted]
PHST- 2023/03/11 00:00 [revised]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 11:13 [entrez]
AID - 10.1007/s00216-023-04665-z [pii]
AID - 10.1007/s00216-023-04665-z [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2023 Jun;415(14):2665-2676. doi: 10.1007/s00216-023-04665-z. 
      Epub 2023 Apr 3.