PMID- 37010645
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230427
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 40
IP  - 5
DP  - 2023 Apr 3
TI  - Understanding the functional relevance of oral neutrophils, phenotype and 
      properties in OSCC.
PG  - 134
LID - 10.1007/s12032-023-02010-z [doi]
AB  - Neutrophils are the predominant white blood cells (WBC) that are recruited to the 
      sites of inflammation and infection. They are acknowledged to perform dual roles 
      by promoting (pro-tumor) or by exhibiting anti-cancer properties (anti-tumor). 
      Neutrophils are characterized based on the changes in phenotype and functional 
      properties. To this context, circulating polymorphonuclear neutrophils (cPMN) and 
      tumor-associated neutrophils (TANs) in cancer biology has been well explored but 
      limited to oral polymorphonuclear neutrophils (oPMNs) in oral squamous cell 
      carcinoma (OSCC). However, oPMNs are eminent in maintaining the healthy oral 
      ecosystem by neutralizing microorganisms. Neutralization process enhances the 
      expression of cell surface markers (CD11b, CD63, CD66, CD66b, CD66c, and CD66e) 
      and inflammatory cytokines (TNF-alpha, IFN-gamma, GM-CSF, and IL-8) and increases the 
      recruitment of neutrophils. Along with the inflammation, it has been reported 
      that CEACAM1 and chemerin also favors the infiltration of neutrophils to the 
      cancer site. This indicates that oPMN might contribute to the aetiology of OSCC. 
      The main objective of this review is to explore, the production and migration of 
      oPMNs to the oral cavity, their phenotypes and possible role in OSCC.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Lenka, Sudhansubala
AU  - Lenka S
AD  - Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan 
      Deemed to be University, Bhubaneswar, Odisha, India.
FAU - Bhola, Rajesh Kumar
AU  - Bhola RK
AD  - Department of Pathology, IMS and SUM Hospital, Siksha 'O' Anusandhan Deemed to be 
      University, Bhubaneswar, Odisha, India.
FAU - Varanasi, Pavankumar R
AU  - Varanasi PR
AD  - Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan 
      Deemed to be University, Bhubaneswar, Odisha, India.
FAU - Bhuyan, Sanat Kumar
AU  - Bhuyan SK
AD  - Department of Oral Medicine and Radiology, Siksha 'O' Anusandhan Deemed to be 
      University, Bhubaneswar, Odisha, India.
FAU - Bhuyan, Ruchi
AU  - Bhuyan R
AUID- ORCID: 0000-0002-4082-8393
AD  - Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan 
      Deemed to be University, Bhubaneswar, Odisha, India. ruchibhuyan@soa.ac.in.
AD  - Department of Oral Pathology and Microbiology, IMS and SUM Hospital, Siksha 'O' 
      Anusandhan (Deemed to be) University, Bhubaneswar, 751003, India. 
      ruchibhuyan@soa.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230403
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
MH  - Humans
MH  - Neutrophils/pathology
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - *Mouth Neoplasms/pathology
MH  - Ecosystem
MH  - Inflammation/metabolism
MH  - Phenotype
MH  - *Head and Neck Neoplasms/pathology
OTO - NOTNLM
OT  - Chemokines
OT  - Circulating neutrophils
OT  - Cytokines
OT  - Oral cancer
OT  - Oral neutrophils
OT  - Surface markers
EDAT- 2023/04/04 06:00
MHDA- 2023/04/05 06:42
CRDT- 2023/04/03 11:18
PHST- 2023/02/05 00:00 [received]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/04/05 06:42 [medline]
PHST- 2023/04/03 11:18 [entrez]
PHST- 2023/04/04 06:00 [pubmed]
AID - 10.1007/s12032-023-02010-z [pii]
AID - 10.1007/s12032-023-02010-z [doi]
PST - epublish
SO  - Med Oncol. 2023 Apr 3;40(5):134. doi: 10.1007/s12032-023-02010-z.